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A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse.
Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD. Galinato MH, et al. Among authors: fannon pavlich mj. Mol Psychiatry. 2018 Mar;23(3):629-638. doi: 10.1038/mp.2017.46. Epub 2017 Mar 28. Mol Psychiatry. 2018. PMID: 28348387 Free PMC article.
Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. Pearn ML, et al. Among authors: fannon pavlich mj. Br J Anaesth. 2018 Apr;120(4):745-760. doi: 10.1016/j.bja.2017.12.033. Epub 2018 Feb 15. Br J Anaesth. 2018. PMID: 29576115 Free PMC article.