Lewis I - Search Results

1

Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.

Hoegenauer K, Soldermann N, Stauffer F, Furet P, Graveleau N, Smith AB, Hebach C, Hollingworth GJ, Lewis I, Gutmann S, Rummel G, Knapp M, Wolf RM, Blanz J, Feifel R, Burkhart C, Zécri F. Hoegenauer K, et al. Among authors: lewis i. ACS Med Chem Lett. 2016 Jun 2;7(8):762-7. doi: 10.1021/acsmedchemlett.6b00119. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563400 Free PMC article.

2

Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.

Hoegenauer K, Soldermann N, Hebach C, Hollingworth GJ, Lewis I, von Matt A, Smith AB, Wolf RM, Wilcken R, Haasen D, Burkhart C, Zécri F. Hoegenauer K, et al. Among authors: lewis i. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5657-5662. doi: 10.1016/j.bmcl.2016.10.069. Epub 2016 Oct 27. Bioorg Med Chem Lett. 2016. PMID: 27816514

3

Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.

Furet P, Salem B, Mesrouze Y, Schmelzle T, Lewis I, Kallen J, Chène P. Furet P, et al. Among authors: lewis i. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2316-2319. doi: 10.1016/j.bmcl.2019.06.022. Epub 2019 Jun 18. Bioorg Med Chem Lett. 2019. PMID: 31235263

4

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Thoma G, Baenteli R, Lewis I, Wagner T, Oberer L, Blum W, Glickman F, Streiff MB, Zerwes HG. Thoma G, et al. Among authors: lewis i. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6185-8. doi: 10.1016/j.bmcl.2009.09.002. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19783143

5

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.

Thoma G, Baenteli R, Lewis I, Jones D, Kovarik J, Streiff MB, Zerwes HG. Thoma G, et al. Among authors: lewis i. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4745-9. doi: 10.1016/j.bmcl.2011.06.070. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21764306

6

A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.

Lewis I, Bauer W, Albert R, Chandramouli N, Pless J, Weckbecker G, Bruns C. Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44. doi: 10.1021/jm021093t. J Med Chem. 2003. PMID: 12773038

7

Recent trends and observations in the design of high-quality screening collections.

Renner S, Popov M, Schuffenhauer A, Roth HJ, Breitenstein W, Marzinzik A, Lewis I, Krastel P, Nigsch F, Jenkins J, Jacoby E. Renner S, et al. Among authors: lewis i. Future Med Chem. 2011 Apr;3(6):751-66. doi: 10.4155/fmc.11.15. Future Med Chem. 2011. PMID: 21554080 Review.

8

SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile.

Bruns C, Lewis I, Briner U, Meno-Tetang G, Weckbecker G. Bruns C, et al. Among authors: lewis i. Eur J Endocrinol. 2002 May;146(5):707-16. doi: 10.1530/eje.0.1460707. Eur J Endocrinol. 2002. PMID: 11980628

9

SOM230: a new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs.

Weckbecker G, Briner U, Lewis I, Bruns C. Weckbecker G, et al. Among authors: lewis i. Endocrinology. 2002 Oct;143(10):4123-30. doi: 10.1210/en.2002-220219. Endocrinology. 2002. PMID: 12239124

10

SOM230: a new therapeutic modality for Cushing's disease.

Lewis I, Schmid HA, Kneuer R, Hoyer D, Silva AP, Weckbecker G, Bruns C, Pless J. Lewis I, et al. Chimia (Aarau). 2014;68(7-8):483-4. doi: 10.2533/chimia.2014.483. Chimia (Aarau). 2014. PMID: 25437387 Free article.

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