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A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.
Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A. Wolf D, et al. Among authors: marki a. Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8. Nat Commun. 2018. PMID: 29410422 Free PMC article.
Leaking chemokines confuse neutrophils.
Marki A, Ley K. Marki A, et al. J Clin Invest. 2020 May 1;130(5):2177-2179. doi: 10.1172/JCI136259. J Clin Invest. 2020. PMID: 32202515 Free PMC article.
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis.
Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K. Marki A, et al. J Exp Med. 2021 Mar 1;218(3):e20200551. doi: 10.1084/jem.20200551. J Exp Med. 2021. PMID: 33275138 Free PMC article.
Biomechanics of Neutrophil Tethers.
Cugno A, Marki A, Ley K. Cugno A, et al. Among authors: marki a. Life (Basel). 2021 May 31;11(6):515. doi: 10.3390/life11060515. Life (Basel). 2021. PMID: 34073130 Free PMC article. Review.
72 results