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Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.
Pirazzi C, Adiels M, Burza MA, Mancina RM, Levin M, Ståhlman M, Taskinen MR, Orho-Melander M, Perman J, Pujia A, Andersson L, Maglio C, Montalcini T, Wiklund O, Borén J, Romeo S. Pirazzi C, et al. Among authors: wiklund o. J Hepatol. 2012 Dec;57(6):1276-82. doi: 10.1016/j.jhep.2012.07.030. Epub 2012 Aug 6. J Hepatol. 2012. PMID: 22878467
The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.
Maglio C, Ericson U, Burza MA, Mancina RM, Pirazzi C, Assarsson JA, Sjöholm K, Baroni MG, Svensson PA, Montalcini T, Pujia A, Sjöström L, Wiklund O, Carlsson LM, Borén J, Orho-Melander M, Romeo S. Maglio C, et al. Among authors: wiklund o. J Clin Endocrinol Metab. 2013 Apr;98(4):E785-9. doi: 10.1210/jc.2012-2831. Epub 2013 Feb 15. J Clin Endocrinol Metab. 2013. PMID: 23418314
The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children.
Mancina RM, Burza MA, Maglio C, Pirazzi C, Sentinelli F, Incani M, Montalcini T, Pujia A, Congiu T, Loche S, Pilia S, Wiklund O, Borén J, Romeo S, Baroni MG. Mancina RM, et al. Among authors: wiklund o. Diabetes Metab Res Rev. 2013 Jul;29(5):413-6. doi: 10.1002/dmrr.2408. Diabetes Metab Res Rev. 2013. PMID: 23463496 Free PMC article.
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.
Pirazzi C, Valenti L, Motta BM, Pingitore P, Hedfalk K, Mancina RM, Burza MA, Indiveri C, Ferro Y, Montalcini T, Maglio C, Dongiovanni P, Fargion S, Rametta R, Pujia A, Andersson L, Ghosal S, Levin M, Wiklund O, Iacovino M, Borén J, Romeo S. Pirazzi C, et al. Among authors: wiklund o. Hum Mol Genet. 2014 Aug 1;23(15):4077-85. doi: 10.1093/hmg/ddu121. Epub 2014 Mar 25. Hum Mol Genet. 2014. PMID: 24670599 Free PMC article.
Statin use and non-alcoholic steatohepatitis in at risk individuals.
Dongiovanni P, Petta S, Mannisto V, Mancina RM, Pipitone R, Karja V, Maggioni M, Kakela P, Wiklund O, Mozzi E, Grimaudo S, Kaminska D, Rametta R, Craxi A, Fargion S, Nobili V, Romeo S, Pihlajamaki J, Valenti L. Dongiovanni P, et al. Among authors: wiklund o. J Hepatol. 2015 Sep;63(3):705-12. doi: 10.1016/j.jhep.2015.05.006. Epub 2015 May 14. J Hepatol. 2015. PMID: 25980762 Free article.
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.
Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, Borén J, Montalcini T, Pujia A, Wiklund O, Hindy G, Spagnuolo R, Motta BM, Pipitone RM, Craxì A, Fargion S, Nobili V, Käkelä P, Kärjä V, Männistö V, Pihlajamäki J, Reilly DF, Castro-Perez J, Kozlitina J, Valenti L, Romeo S. Mancina RM, et al. Among authors: wiklund o. Gastroenterology. 2016 May;150(5):1219-1230.e6. doi: 10.1053/j.gastro.2016.01.032. Epub 2016 Feb 2. Gastroenterology. 2016. PMID: 26850495 Free PMC article.
PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.
Pingitore P, Dongiovanni P, Motta BM, Meroni M, Lepore SM, Mancina RM, Pelusi S, Russo C, Caddeo A, Rossi G, Montalcini T, Pujia A, Wiklund O, Valenti L, Romeo S. Pingitore P, et al. Among authors: wiklund o. Hum Mol Genet. 2016 Dec 1;25(23):5212-5222. doi: 10.1093/hmg/ddw341. Hum Mol Genet. 2016. PMID: 27742777 Free PMC article.
248 results