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Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.
Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo CW, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. Ai D, et al. Among authors: rader dj. J Clin Invest. 2012 May;122(5):1677-87. doi: 10.1172/JCI61248. Epub 2012 Apr 2. J Clin Invest. 2012. PMID: 22466652 Free PMC article.
Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.
Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ. Kassim SH, et al. Among authors: rader dj. Hum Gene Ther. 2013 Jan;24(1):19-26. doi: 10.1089/hum.2012.108. Epub 2012 Nov 14. Hum Gene Ther. 2013. PMID: 22985273 Free PMC article.
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.
Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ; Phase 3 HoFH Lomitapide Study investigators. Cuchel M, et al. Among authors: rader dj. Lancet. 2013 Jan 5;381(9860):40-6. doi: 10.1016/S0140-6736(12)61731-0. Epub 2012 Nov 2. Lancet. 2013. PMID: 23122768 Free PMC article. Clinical Trial.
945 results