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Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP. Eil R, et al. Among authors: linehan wm. Nature. 2016 Sep 22;537(7621):539-543. doi: 10.1038/nature19364. Epub 2016 Sep 14. Nature. 2016. PMID: 27626381 Free PMC article.
Reprogramming tumour-associated macrophages to outcompete cancer cells.
Zhang X, Li S, Malik I, Do MH, Ji L, Chou C, Shi W, Capistrano KJ, Zhang J, Hsu TW, Nixon BG, Xu K, Wang X, Ballabio A, Schmidt LS, Linehan WM, Li MO. Zhang X, et al. Among authors: linehan wm. Nature. 2023 Jul;619(7970):616-623. doi: 10.1038/s41586-023-06256-5. Epub 2023 Jun 28. Nature. 2023. PMID: 37380769 Free PMC article.
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.
Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM. Hasumi Y, et al. Among authors: linehan wm. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7. doi: 10.1073/pnas.0908853106. Epub 2009 Oct 22. Proc Natl Acad Sci U S A. 2009. PMID: 19850877 Free PMC article.
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer.
Cherkasova E, Malinzak E, Rao S, Takahashi Y, Senchenko VN, Kudryavtseva AV, Nickerson ML, Merino M, Hong JA, Schrump DS, Srinivasan R, Linehan WM, Tian X, Lerman MI, Childs RW. Cherkasova E, et al. Among authors: linehan wm. Oncogene. 2011 Nov 24;30(47):4697-706. doi: 10.1038/onc.2011.179. Epub 2011 May 23. Oncogene. 2011. PMID: 21602888 Free PMC article.
799 results