Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes.
Matsumoto T, Noguchi E, Ishida K, Kobayashi T, Yamada N, Kamata K.
Matsumoto T, et al.
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1165-H1176. doi: 10.1152/ajpheart.00486.2008. Epub 2008 Jul 18.
Am J Physiol Heart Circ Physiol. 2008.
PMID: 18641273
Free article.
We previously reported that in mesenteric arteries from aged Otsuka Long-Evans Tokushima fatty (OLETF) rats (a type 2 diabetes model) endothelium-derived hyperpolarizing factor (EDHF)-type relaxation is impaired while endothelium-derived contracting factor (EDCF)-mediated contrac …
We previously reported that in mesenteric arteries from aged Otsuka Long-Evans Tokushima fatty (OLETF) rats (a type 2 diabetes model) endoth …