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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M. Brand A, et al. Among authors: kreutz m. Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011. Epub 2016 Sep 15. Cell Metab. 2016. PMID: 27641098 Free article.
Inhibitory effect of tumor cell-derived lactic acid on human T cells.
Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, Gottfried E, Schwarz S, Rothe G, Hoves S, Renner K, Timischl B, Mackensen A, Kunz-Schughart L, Andreesen R, Krause SW, Kreutz M. Fischer K, et al. Among authors: kreutz m. Blood. 2007 May 1;109(9):3812-9. doi: 10.1182/blood-2006-07-035972. Epub 2007 Jan 25. Blood. 2007. PMID: 17255361 Free article. Clinical Trial.
Tumor-induced modulation of dendritic cell function.
Gottfried E, Kreutz M, Mackensen A. Gottfried E, et al. Among authors: kreutz m. Cytokine Growth Factor Rev. 2008 Feb;19(1):65-77. doi: 10.1016/j.cytogfr.2007.10.008. Epub 2007 Dec 3. Cytokine Growth Factor Rev. 2008. PMID: 18061513 Review.
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis.
Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Schölmerich J, Oefner PJ, Kreutz M, Bosserhoff AK, Hellerbrand C. Amann T, et al. Among authors: kreutz m. Am J Pathol. 2009 Apr;174(4):1544-52. doi: 10.2353/ajpath.2009.080596. Epub 2009 Mar 12. Am J Pathol. 2009. PMID: 19286567 Free PMC article.
Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes.
Dietl K, Renner K, Dettmer K, Timischl B, Eberhart K, Dorn C, Hellerbrand C, Kastenberger M, Kunz-Schughart LA, Oefner PJ, Andreesen R, Gottfried E, Kreutz MP. Dietl K, et al. Among authors: kreutz mp. J Immunol. 2010 Feb 1;184(3):1200-9. doi: 10.4049/jimmunol.0902584. Epub 2009 Dec 21. J Immunol. 2010. PMID: 20026743
349 results