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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Qi W, Zhao K, Gu J, Huang Y, Wang Y, Zhang H, Zhang M, Zhang J, Yu Z, Li L, Teng L, Chuai S, Zhang C, Zhao M, Chan H, Chen Z, Fang D, Fei Q, Feng L, Feng L, Gao Y, Ge H, Ge X, Li G, Lingel A, Lin Y, Liu Y, Luo F, Shi M, Wang L, Wang Z, Yu Y, Zeng J, Zeng C, Zhang L, Zhang Q, Zhou S, Oyang C, Atadja P, Li E. Qi W, et al. Among authors: ge h, ge x. Nat Chem Biol. 2017 Apr;13(4):381-388. doi: 10.1038/nchembio.2304. Epub 2017 Jan 30. Nat Chem Biol. 2017. PMID: 28135235
TET1 promotes RXRα expression and adipogenesis through DNA demethylation.
Qian H, Zhao J, Yang X, Wu S, An Y, Qu Y, Li Z, Ge H, Li E, Qi W. Qian H, et al. Among authors: ge h. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jun;1866(6):158919. doi: 10.1016/j.bbalip.2021.158919. Epub 2021 Mar 6. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33684567
Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer.
Shi C, Wang Q, Liao X, Ge H, Huo G, Zhang L, Chen N, Zhai X, Hong Y, Wang L, Han Y, Xiao W, Wang Z, Shi W, Mao Y, Yu J, Xia G, Liu Y. Shi C, et al. Among authors: ge h. Eur J Med Chem. 2019 Sep 15;178:352-364. doi: 10.1016/j.ejmech.2019.06.005. Epub 2019 Jun 4. Eur J Med Chem. 2019. PMID: 31200237
The role of pericyte in ocular vascular diseases.
Shi LJ, Ge H, Ye F, Li X, Jiang Q. Shi LJ, et al. Among authors: ge h. J Biomed Res. 2024 Apr 25:1-10. doi: 10.7555/JBR.37.20230314. Online ahead of print. J Biomed Res. 2024. PMID: 38808554
2,917 results