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The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.
Roncagalli R, Cucchetti M, Jarmuzynski N, Grégoire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M, Malissen B. Roncagalli R, et al. Among authors: liang y. J Exp Med. 2016 Oct 17;213(11):2437-2457. doi: 10.1084/jem.20160579. Epub 2016 Sep 19. J Exp Med. 2016. PMID: 27647348 Free PMC article.
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Roncagalli R, et al. Among authors: liang y. Nat Immunol. 2014 Apr;15(4):384-392. doi: 10.1038/ni.2843. Epub 2014 Mar 2. Nat Immunol. 2014. PMID: 24584089 Free PMC article.
Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.
Voisinne G, Kersse K, Chaoui K, Lu L, Chaix J, Zhang L, Goncalves Menoita M, Girard L, Ounoughene Y, Wang H, Burlet-Schiltz O, Luche H, Fiore F, Malissen M, Gonzalez de Peredo A, Liang Y, Roncagalli R, Malissen B. Voisinne G, et al. Among authors: liang y. Nat Immunol. 2019 Nov;20(11):1530-1541. doi: 10.1038/s41590-019-0489-8. Epub 2019 Oct 7. Nat Immunol. 2019. PMID: 31591574 Free PMC article.
Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice.
Lu L, Li T, Feng X, Liu Z, Liu Y, Chao T, Gu Y, Huang R, Zhang F, He L, Zhou B, Kong E, Liu Z, Wang X, Chen Z, Wang H, Malissen M, Malissen B, Zhang L, Liang Y. Lu L, et al. Among authors: liang y. PLoS Pathog. 2022 Jun 6;18(6):e1010596. doi: 10.1371/journal.ppat.1010596. eCollection 2022 Jun. PLoS Pathog. 2022. PMID: 35666747 Free PMC article.
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