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Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
Brägelmann J, Klümper N, Offermann A, von Mässenhausen A, Böhm D, Deng M, Queisser A, Sanders C, Syring I, Merseburger AS, Vogel W, Sievers E, Vlasic I, Carlsson J, Andrén O, Brossart P, Duensing S, Svensson MA, Adler D, Kirfel J, Perner S. Brägelmann J, et al. Among authors: sievers e. Clin Cancer Res. 2017 Apr 1;23(7):1829-1840. doi: 10.1158/1078-0432.CCR-16-0094. Epub 2016 Sep 27. Clin Cancer Res. 2017. PMID: 27678455
Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT.
Lemster AL, Sievers E, Pasternack H, Lazar-Karsten P, Klümper N, Sailer V, Offermann A, Brägelmann J, Perner S, Kirfel J. Lemster AL, et al. Among authors: sievers e. Cancers (Basel). 2022 Apr 8;14(8):1894. doi: 10.3390/cancers14081894. Cancers (Basel). 2022. PMID: 35454801 Free PMC article.
SRC signaling is crucial in the growth of synovial sarcoma cells.
Michels S, Trautmann M, Sievers E, Kindler D, Huss S, Renner M, Friedrichs N, Kirfel J, Steiner S, Endl E, Wurst P, Heukamp L, Penzel R, Larsson O, Kawai A, Tanaka S, Sonobe H, Schirmacher P, Mechtersheimer G, Wardelmann E, Büttner R, Hartmann W. Michels S, et al. Among authors: sievers e. Cancer Res. 2013 Apr 15;73(8):2518-28. doi: 10.1158/0008-5472.CAN-12-3023. Epub 2013 Apr 11. Cancer Res. 2013. PMID: 23580575
SRC inhibition represents a potential therapeutic strategy in liposarcoma.
Sievers E, Trautmann M, Kindler D, Huss S, Gruenewald I, Dirksen U, Renner M, Mechtersheimer G, Pedeutour F, Åman P, Nishio J, Schildhaus HU, Kirfel J, Schirmacher P, Wardelmann E, Buettner R, Hartmann W. Sievers E, et al. Int J Cancer. 2015 Dec 1;137(11):2578-88. doi: 10.1002/ijc.29645. Epub 2015 Jul 6. Int J Cancer. 2015. PMID: 26084847 Free article.
Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma.
Friedrichs N, Trautmann M, Endl E, Sievers E, Kindler D, Wurst P, Czerwitzki J, Steiner S, Renner M, Penzel R, Koch A, Larsson O, Tanaka S, Kawai A, Schirmacher P, Mechtersheimer G, Wardelmann E, Buettner R, Hartmann W. Friedrichs N, et al. Among authors: sievers e. Int J Cancer. 2011 Oct 1;129(7):1564-75. doi: 10.1002/ijc.25829. Epub 2011 Mar 4. Int J Cancer. 2011. PMID: 21128248 Free article.
SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.
Trautmann M, Sievers E, Aretz S, Kindler D, Michels S, Friedrichs N, Renner M, Kirfel J, Steiner S, Huss S, Koch A, Penzel R, Larsson O, Kawai A, Tanaka S, Sonobe H, Waha A, Schirmacher P, Mechtersheimer G, Wardelmann E, Büttner R, Hartmann W. Trautmann M, et al. Among authors: sievers e. Oncogene. 2014 Oct 16;33(42):5006-16. doi: 10.1038/onc.2013.443. Epub 2013 Oct 28. Oncogene. 2014. PMID: 24166495
Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration.
Elfimova N, Sievers E, Eischeid H, Kwiecinski M, Noetel A, Hunt H, Becker D, Frommolt P, Quasdorff M, Steffen HM, Nürnberg P, Büttner R, Teufel A, Dienes HP, Drebber U, Odenthal M. Elfimova N, et al. Among authors: sievers e. Biochim Biophys Acta. 2013 May;1833(5):1190-8. doi: 10.1016/j.bbamcr.2013.01.023. Epub 2013 Feb 5. Biochim Biophys Acta. 2013. PMID: 23391410 Free article.
165 results