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Exosome secretion is a key pathway for clearance of pathological TDP-43.
Iguchi Y, Eid L, Parent M, Soucy G, Bareil C, Riku Y, Kawai K, Takagi S, Yoshida M, Katsuno M, Sobue G, Julien JP. Iguchi Y, et al. Among authors: kawai k. Brain. 2016 Dec;139(Pt 12):3187-3201. doi: 10.1093/brain/aww237. Epub 2016 Sep 27. Brain. 2016. PMID: 27679482 Free PMC article.
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka K, Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Tanaka F, Sobue G. Iguchi Y, et al. Among authors: kawai k. Brain. 2013 May;136(Pt 5):1371-82. doi: 10.1093/brain/awt029. Epub 2013 Feb 28. Brain. 2013. PMID: 23449777
[Dysfunction of dynactin 1 in motor neuron degeneration].
Katsuno M, Ikenaka K, Kawai K, Sobue G. Katsuno M, et al. Among authors: kawai k. Rinsho Shinkeigaku. 2013;53(11):1084-6. doi: 10.5692/clinicalneurol.53.1084. Rinsho Shinkeigaku. 2013. PMID: 24291886 Review. Japanese.
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
Araki K, Araki A, Honda D, Izumoto T, Hashizume A, Hijikata Y, Yamada S, Iguchi Y, Hara A, Ikumi K, Kawai K, Ishigaki S, Nakamichi Y, Tsunekawa S, Seino Y, Yamamoto A, Takayama Y, Hidaka S, Tominaga M, Ohara-Imaizumi M, Suzuki A, Ishiguro H, Enomoto A, Yoshida M, Arima H, Muramatsu SI, Sobue G, Katsuno M. Araki K, et al. Among authors: kawai k. J Clin Invest. 2019 Jul 29;129(9):3578-3593. doi: 10.1172/JCI124481. eCollection 2019 Jul 29. J Clin Invest. 2019. PMID: 31355778 Free PMC article.
Disruption of axonal transport in motor neuron diseases.
Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G. Ikenaka K, et al. Among authors: kawai k. Int J Mol Sci. 2012;13(1):1225-1238. doi: 10.3390/ijms13011225. Epub 2012 Jan 23. Int J Mol Sci. 2012. PMID: 22312314 Free PMC article. Review.
3,867 results