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Translating genome-wide association findings into new therapeutics for psychiatry.
Breen G, Li Q, Roth BL, O'Donnell P, Didriksen M, Dolmetsch R, O'Reilly PF, Gaspar HA, Manji H, Huebel C, Kelsoe JR, Malhotra D, Bertolino A, Posthuma D, Sklar P, Kapur S, Sullivan PF, Collier DA, Edenberg HJ. Breen G, et al. Nat Neurosci. 2016 Oct 26;19(11):1392-1396. doi: 10.1038/nn.4411. Nat Neurosci. 2016. PMID: 27786187 Free PMC article. Review.
Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. Urs NM, et al. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186. doi: 10.1073/pnas.1614347113. Epub 2016 Dec 1. Proc Natl Acad Sci U S A. 2016. PMID: 27911814 Free PMC article.
Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans.
Dao DT, Mahon PB, Cai X, Kovacsics CE, Blackwell RA, Arad M, Shi J, Zandi PP, O'Donnell P; Bipolar Genome Study (BiGS) Consortium; Knowles JA, Weissman MM, Coryell W, Scheftner WA, Lawson WB, Levinson DF, Thompson SM, Potash JB, Gould TD. Dao DT, et al. Biol Psychiatry. 2010 Nov 1;68(9):801-10. doi: 10.1016/j.biopsych.2010.06.019. Epub 2010 Aug 17. Biol Psychiatry. 2010. PMID: 20723887 Free PMC article.
Transcriptome-wide association study reveals two genes that influence mismatch negativity.
Bhat A, Irizar H, Thygesen JH, Kuchenbaecker K, Pain O, Adams RA, Zartaloudi E, Harju-Seppänen J, Austin-Zimmerman I, Wang B, Muir R, Summerfelt A, Du XM, Bruce H, O'Donnell P, Srivastava DP, Friston K, Hong LE, Hall MH, Bramon E. Bhat A, et al. Cell Rep. 2021 Mar 16;34(11):108868. doi: 10.1016/j.celrep.2021.108868. Cell Rep. 2021. PMID: 33730571 Free PMC article.
955 results