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PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.
Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM. Beecham GW, et al. Among authors: dykxhoorn dm. Neurology. 2015 Mar 10;84(10):972-80. doi: 10.1212/WNL.0000000000001332. Epub 2015 Feb 6. Neurology. 2015. PMID: 25663231 Free PMC article.
C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.
Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. Esanov R, et al. Among authors: dykxhoorn dm. Exp Neurol. 2016 Mar;277:171-177. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31. Exp Neurol. 2016. PMID: 26746986 Free PMC article.
Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease.
Young JI, Sivasankaran SK, Wang L, Ali A, Mehta A, Davis DA, Dykxhoorn DM, Petito CK, Beecham GW, Martin ER, Mash DC, Pericak-Vance M, Scott WK, Montine TJ, Vance JM. Young JI, et al. Among authors: dykxhoorn dm. Neurol Genet. 2019 Jun 24;5(4):e342. doi: 10.1212/NXG.0000000000000342. eCollection 2019 Aug. Neurol Genet. 2019. PMID: 31403079 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35109243
Bromodomain inhibitors regulate the C9ORF72 locus in ALS.
Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, Wahlestedt C. Zeier Z, et al. Among authors: dykxhoorn dm. Exp Neurol. 2015 Sep;271:241-50. doi: 10.1016/j.expneurol.2015.06.017. Epub 2015 Jun 20. Exp Neurol. 2015. PMID: 26099177 Free PMC article.
101 results