Varadarajan R - Search Results

1

Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies.

Kesavardhana S, Das R, Citron M, Datta R, Ecto L, Srilatha NS, DiStefano D, Swoyer R, Joyce JG, Dutta S, LaBranche CC, Montefiori DC, Flynn JA, Varadarajan R. Kesavardhana S, et al. Among authors: varadarajan r. J Biol Chem. 2017 Jan 6;292(1):278-291. doi: 10.1074/jbc.M116.725614. Epub 2016 Nov 22. J Biol Chem. 2017. PMID: 27879316 Free PMC article.

2

Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states.

Ratnaparkhi GS, Varadarajan R. Ratnaparkhi GS, et al. Among authors: varadarajan r. J Biol Chem. 2001 Aug 3;276(31):28789-98. doi: 10.1074/jbc.M101906200. Epub 2001 May 23. J Biol Chem. 2001. PMID: 11373282 Free article.

3

Electron spin resonance and fluorescence studies of the bound-state conformation of a model protein substrate to the chaperone SecB.

Panse VG, Beena K, Philipp R, Trommer WE, Vogel PD, Varadarajan R. Panse VG, et al. Among authors: varadarajan r. J Biol Chem. 2001 Sep 7;276(36):33681-8. doi: 10.1074/jbc.M104466200. Epub 2001 Jul 2. J Biol Chem. 2001. PMID: 11435433 Free article.

4

A procedure for detection and quantitation of cavity volumes proteins. Application to measure the strength of the hydrophobic driving force in protein folding.

Chakravarty S, Bhinge A, Varadarajan R. Chakravarty S, et al. Among authors: varadarajan r. J Biol Chem. 2002 Aug 30;277(35):31345-53. doi: 10.1074/jbc.M201373200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070144 Free article.

5

Characterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9: implications for targeting the CD4i epitope in human immunodeficiency virus vaccine design.

Varadarajan R, Sharma D, Chakraborty K, Patel M, Citron M, Sinha P, Yadav R, Rashid U, Kennedy S, Eckert D, Geleziunas R, Bramhill D, Schleif W, Liang X, Shiver J. Varadarajan R, et al. J Virol. 2005 Feb;79(3):1713-23. doi: 10.1128/JVI.79.3.1713-1723.2005. J Virol. 2005. PMID: 15650196 Free PMC article.

6

NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water.

Chakraborty K, Shivakumar P, Raghothama S, Varadarajan R. Chakraborty K, et al. Among authors: varadarajan r. Biochem J. 2005 Sep 1;390(Pt 2):573-81. doi: 10.1042/BJ20050442. Biochem J. 2005. PMID: 15896194 Free PMC article.

7

Protein minimization of the gp120 binding region of human CD4.

Sharma D, Balamurali MM, Chakraborty K, Kumaran S, Jeganathan S, Rashid U, Ingallinella P, Varadarajan R. Sharma D, et al. Among authors: varadarajan r. Biochemistry. 2005 Dec 13;44(49):16192-202. doi: 10.1021/bi051120s. Biochemistry. 2005. PMID: 16331979

8

Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies.

Chakraborty K, Durani V, Miranda ER, Citron M, Liang X, Schleif W, Joyce JG, Varadarajan R. Chakraborty K, et al. Among authors: varadarajan r. Biochem J. 2006 Nov 1;399(3):483-91. doi: 10.1042/BJ20060588. Biochem J. 2006. PMID: 16827663 Free PMC article.

9

Design of a non-glycosylated outer domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies.

Bhattacharyya S, Rajan RE, Swarupa Y, Rathore U, Verma A, Udaykumar R, Varadarajan R. Bhattacharyya S, et al. Among authors: varadarajan r. J Biol Chem. 2010 Aug 27;285(35):27100-27110. doi: 10.1074/jbc.M110.152272. Epub 2010 Jun 17. J Biol Chem. 2010. PMID: 20558728 Free PMC article.

10

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge.

Bommakanti G, Citron MP, Hepler RW, Callahan C, Heidecker GJ, Najar TA, Lu X, Joyce JG, Shiver JW, Casimiro DR, ter Meulen J, Liang X, Varadarajan R. Bommakanti G, et al. Among authors: varadarajan r. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13701-6. doi: 10.1073/pnas.1007465107. Epub 2010 Jul 6. Proc Natl Acad Sci U S A. 2010. PMID: 20615991 Free PMC article.

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