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Protonation states of the tryptophan synthase internal aldimine active site from solid-state NMR spectroscopy: direct observation of the protonated Schiff base linkage to pyridoxal-5'-phosphate.
Caulkins BG, Bastin B, Yang C, Neubauer TJ, Young RP, Hilario E, Huang YM, Chang CE, Fan L, Dunn MF, Marsella MJ, Mueller LJ. Caulkins BG, et al. Among authors: mueller lj. J Am Chem Soc. 2014 Sep 17;136(37):12824-7. doi: 10.1021/ja506267d. Epub 2014 Sep 3. J Am Chem Soc. 2014. PMID: 25148001 Free PMC article.
Discovery of antimicrobial agent targeting tryptophan synthase.
Bosken YK, Ai R, Hilario E, Ghosh RK, Dunn MF, Kan SH, Niks D, Zhou H, Ma W, Mueller LJ, Fan L, Chang CA. Bosken YK, et al. Among authors: mueller lj. Protein Sci. 2022 Feb;31(2):432-442. doi: 10.1002/pro.4236. Epub 2021 Nov 26. Protein Sci. 2022. PMID: 34767267 Free PMC article.
Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate.
Holmes JB, Liu V, Caulkins BG, Hilario E, Ghosh RK, Drago VN, Young RP, Romero JA, Gill AD, Bogie PM, Paulino J, Wang X, Riviere G, Bosken YK, Struppe J, Hassan A, Guidoulianov J, Perrone B, Mentink-Vigier F, Chang CA, Long JR, Hooley RJ, Mueser TC, Dunn MF, Mueller LJ. Holmes JB, et al. Among authors: mueller lj. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2109235119. doi: 10.1073/pnas.2109235119. Proc Natl Acad Sci U S A. 2022. PMID: 34996869 Free PMC article.
Effect of protonation on the conformation of cinchonidine.
Olsen RA, Borchardt D, Mink L, Agarwal A, Mueller LJ, Zaera F. Olsen RA, et al. Among authors: mueller lj. J Am Chem Soc. 2006 Dec 13;128(49):15594-5. doi: 10.1021/ja066989s. J Am Chem Soc. 2006. PMID: 17147361
31P NMR investigation of backbone dynamics in DNA binding sites.
Tian Y, Kayatta M, Shultis K, Gonzalez A, Mueller LJ, Hatcher ME. Tian Y, et al. Among authors: mueller lj. J Phys Chem B. 2009 Mar 5;113(9):2596-603. doi: 10.1021/jp711203m. J Phys Chem B. 2009. PMID: 18717548 Free PMC article.
74 results