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A comprehensive map of molecular drug targets.
Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI, Overington JP. Santos R, et al. Among authors: ursu o. Nat Rev Drug Discov. 2017 Jan;16(1):19-34. doi: 10.1038/nrd.2016.230. Epub 2016 Dec 2. Nat Rev Drug Discov. 2017. PMID: 27910877 Free PMC article. Review.
Unexplored therapeutic opportunities in the human genome.
Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma'ayan A, Malovannaya A, Mani S, Mathias SL, McManus MT, Meehan TF, von Mering C, Muthas D, Nguyen DT, Overington JP, Papadatos G, Qin J, Reich C, Roth BL, Schürer SC, Simeonov A, Sklar LA, Southall N, Tomita S, Tudose I, Ursu O, Vidovic D, Waller A, Westergaard D, Yang JJ, Zahoránszky-Köhalmi G. Oprea TI, et al. Among authors: ursu o. Nat Rev Drug Discov. 2018 May;17(5):317-332. doi: 10.1038/nrd.2018.14. Epub 2018 Mar 23. Nat Rev Drug Discov. 2018. PMID: 29472638 Free PMC article. Review.
Emerging trends in the discovery of natural product antibacterials.
Bologa CG, Ursu O, Oprea TI, Melançon CE 3rd, Tegos GP. Bologa CG, et al. Among authors: ursu o. Curr Opin Pharmacol. 2013 Oct;13(5):678-87. doi: 10.1016/j.coph.2013.07.002. Epub 2013 Jul 24. Curr Opin Pharmacol. 2013. PMID: 23890825 Free PMC article. Review.
BDDCS, the Rule of 5 and drugability.
Benet LZ, Hosey CM, Ursu O, Oprea TI. Benet LZ, et al. Among authors: ursu o. Adv Drug Deliv Rev. 2016 Jun 1;101:89-98. doi: 10.1016/j.addr.2016.05.007. Epub 2016 May 13. Adv Drug Deliv Rev. 2016. PMID: 27182629 Free PMC article. Review.
DrugCentral: online drug compendium.
Ursu O, Holmes J, Knockel J, Bologa CG, Yang JJ, Mathias SL, Nelson SJ, Oprea TI. Ursu O, et al. Nucleic Acids Res. 2017 Jan 4;45(D1):D932-D939. doi: 10.1093/nar/gkw993. Epub 2016 Oct 26. Nucleic Acids Res. 2017. PMID: 27789690 Free PMC article.
Pharos: Collating protein information to shed light on the druggable genome.
Nguyen DT, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, Hersey A, Holmes J, Jensen LJ, Karlsson A, Liu G, Ma'ayan A, Mandava G, Mani S, Mehta S, Overington J, Patel J, Rouillard AD, Schürer S, Sheils T, Simeonov A, Sklar LA, Southall N, Ursu O, Vidovic D, Waller A, Yang J, Jadhav A, Oprea TI, Guha R. Nguyen DT, et al. Among authors: ursu o. Nucleic Acids Res. 2017 Jan 4;45(D1):D995-D1002. doi: 10.1093/nar/gkw1072. Epub 2016 Nov 29. Nucleic Acids Res. 2017. PMID: 27903890 Free PMC article.
Drug target ontology to classify and integrate drug discovery data.
Lin Y, Mehta S, Küçük-McGinty H, Turner JP, Vidovic D, Forlin M, Koleti A, Nguyen DT, Jensen LJ, Guha R, Mathias SL, Ursu O, Stathias V, Duan J, Nabizadeh N, Chung C, Mader C, Visser U, Yang JJ, Bologa CG, Oprea TI, Schürer SC. Lin Y, et al. Among authors: ursu o. J Biomed Semantics. 2017 Nov 9;8(1):50. doi: 10.1186/s13326-017-0161-x. J Biomed Semantics. 2017. PMID: 29122012 Free PMC article.
Novel drug targets in 2018.
Ursu O, Glick M, Oprea T. Ursu O, et al. Nat Rev Drug Discov. 2019 Mar 26. doi: 10.1038/d41573-019-00052-5. Online ahead of print. Nat Rev Drug Discov. 2019. PMID: 31048796 No abstract available.
75 results