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Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.
J Biol Chem. 2017.
PMID: 27932461
Free PMC article.
Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.
Chenge J, Kavanagh ME, Driscoll MD, McLean KJ, Young DB, Cortes T, Matak-Vinkovic D, Levy CW, Rigby SE, Leys D, Abell C, Munro AW.
Chenge J, et al.
Sci Rep. 2016 May 26;6:26628. doi: 10.1038/srep26628.
Sci Rep. 2016.
PMID: 27225995
Free PMC article.
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Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
Kavanagh ME, Chenge J, Zoufir A, McLean KJ, Coyne AG, Bender A, Munro AW, Abell C.
Kavanagh ME, et al.
Biochemistry. 2017 Mar 21;56(11):1559-1572. doi: 10.1021/acs.biochem.6b00954. Epub 2017 Mar 6.
Biochemistry. 2017.
PMID: 28169518
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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
Wright WC, Chenge J, Wang J, Girvan HM, Yang L, Chai SC, Huber AD, Wu J, Oladimeji PO, Munro AW, Chen T.
Wright WC, et al.
J Med Chem. 2020 Feb 13;63(3):1415-1433. doi: 10.1021/acs.jmedchem.9b02067. Epub 2020 Jan 22.
J Med Chem. 2020.
PMID: 31965799
Free PMC article.
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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Wang J, Buchman CD, Seetharaman J, Miller DJ, Huber AD, Wu J, Chai SC, Garcia-Maldonado E, Wright WC, Chenge J, Chen T.
Wang J, et al.
J Am Chem Soc. 2021 Nov 10;143(44):18467-18480. doi: 10.1021/jacs.1c07066. Epub 2021 Oct 14.
J Am Chem Soc. 2021.
PMID: 34648292
Free PMC article.
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Structural Perspectives of the CYP3A Family and Their Small Molecule Modulators in Drug Metabolism.
Wright WC, Chenge J, Chen T.
Wright WC, et al.
Liver Res. 2019 Dec;3(3-4):132-142. doi: 10.1016/j.livres.2019.08.001. Epub 2019 Aug 29.
Liver Res. 2019.
PMID: 32789028
Free PMC article.
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