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Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW. Chenge JT, et al. Among authors: leys d. J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8. J Biol Chem. 2017. PMID: 27932461 Free PMC article.
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis.
Mowat CG, Leys D, McLean KJ, Rivers SL, Richmond A, Munro AW, Ortiz Lombardia M, Alzari PM, Reid GA, Chapman SK, Walkinshaw MD. Mowat CG, et al. Among authors: leys d. Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):704-5. doi: 10.1107/s0907444902002676. Epub 2002 Mar 22. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11914502 Free article.
P450 BM3: the very model of a modern flavocytochrome.
Munro AW, Leys DG, McLean KJ, Marshall KR, Ost TW, Daff S, Miles CS, Chapman SK, Lysek DA, Moser CC, Page CC, Dutton PL. Munro AW, et al. Trends Biochem Sci. 2002 May;27(5):250-7. doi: 10.1016/s0968-0004(02)02086-8. Trends Biochem Sci. 2002. PMID: 12076537 Review.
The TB structural genomics consortium: providing a structural foundation for drug discovery.
Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W Jr, Terwilliger TC. Goulding CW, et al. Among authors: leys d. Curr Drug Targets Infect Disord. 2002 Jun;2(2):121-41. doi: 10.2174/1568005023342551. Curr Drug Targets Infect Disord. 2002. PMID: 12462144 Review.
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.
Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W Jr, Alber T, Rupp B. Terwilliger TC, et al. Among authors: leys d. Tuberculosis (Edinb). 2003;83(4):223-49. doi: 10.1016/s1472-9792(03)00051-9. Tuberculosis (Edinb). 2003. PMID: 12906835 Review.
Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.
Girvan HM, Marshall KR, Lawson RJ, Leys D, Joyce MG, Clarkson J, Smith WE, Cheesman MR, Munro AW. Girvan HM, et al. Among authors: leys d. J Biol Chem. 2004 May 28;279(22):23274-86. doi: 10.1074/jbc.M401716200. Epub 2004 Mar 12. J Biol Chem. 2004. PMID: 15020591 Free article.
Glutamate coordination of the heme iron is confirmed by structural studies of the A264E mutant (Joyce, M. G., Girvan, H. M., Munro, A. W., and Leys, D. (2004) J. Biol. Chem. 279, 23287-23293)....
Glutamate coordination of the heme iron is confirmed by structural studies of the A264E mutant (Joyce, M. G., Girvan, H. M., Munro, A. W., a …
826 results