Beadle JR - Search Results

1

Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.

Beadle JR, Valiaeva N, Yang G, Yu JH, Broker TR, Aldern KA, Harden EA, Keith KA, Prichard MN, Hartman T, Buckheit RW Jr, Chow LT, Hostetler KY. Beadle JR, et al. J Med Chem. 2016 Dec 8;59(23):10470-10478. doi: 10.1021/acs.jmedchem.6b00659. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933957

2

Lipid prodrugs of phosphonoacids: greatly enhanced antiviral activity of 1-O-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, in vitro.

Hostetler KY, Kini GD, Beadle JR, Aldern KA, Gardner MF, Border R, Kumar R, Barshak L, Sridhar CN, Wheeler CJ, Richman DD. Hostetler KY, et al. Among authors: beadle jr. Antiviral Res. 1996 Jun;31(1-2):59-67. doi: 10.1016/0166-3542(96)00947-3. Antiviral Res. 1996. PMID: 8793009

3

Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro.

Hostetler KY, Beadle JR, Kini GD, Gardner MF, Wright KN, Wu TH, Korba BA. Hostetler KY, et al. Among authors: beadle jr. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22. doi: 10.1016/s0006-2952(97)82446-x. Biochem Pharmacol. 1997. PMID: 9256156 Free article.

4

Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV.

Kini GD, Beadle JR, Xie H, Aldern KA, Richman DD, Hostetler KY. Kini GD, et al. Among authors: beadle jr. Antiviral Res. 1997 Sep;36(1):43-53. doi: 10.1016/s0166-3542(97)00039-9. Antiviral Res. 1997. PMID: 9330760

5

Synthesis and antiviral activity of 1-O-octadecyl-2-O-alkyl-sn-glycero-3-foscarnet conjugates in human cytomegalovirus-infected cells.

Kini GD, Hostetler SE, Beadle JR, Aldern KA. Kini GD, et al. Among authors: beadle jr. Antiviral Res. 1997 Nov;36(2):115-24. doi: 10.1016/s0166-3542(97)00048-x. Antiviral Res. 1997. PMID: 9443668

6

Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells.

Beadle JR, Kini GD, Aldern KA, Gardner MF, Wright KN, Richman DD, Hostetler KY. Beadle JR, et al. Antivir Chem Chemother. 1998 Jan;9(1):33-40. doi: 10.1177/095632029800900104. Antivir Chem Chemother. 1998. PMID: 9875375

7

Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me), a novel lipid antiviral prodrug for intraocular drug delivery.

Cheng L, Hostetler KY, Gardner MF, Avila CP Jr, Bergeron-Lynn G, Keefe KS, Beadle JR, Wiley CA, Freeman WR. Cheng L, et al. Among authors: beadle jr. J Ocul Pharmacol Ther. 1999 Aug;15(4):363-77. doi: 10.1089/jop.1999.15.363. J Ocul Pharmacol Ther. 1999. PMID: 10463875

8

Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.

Beadle JR, Kini GD, Aldern KA, Gardner MF, Wright KN, Rybak RJ, Kern ER, Hostetler KY. Beadle JR, et al. Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):471-9. doi: 10.1080/15257770008033022. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 10772728

9

Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.

Cheng L, Hostetler KY, Chaidhawangul S, Gardner MF, Beadle JR, Keefe KS, Bergeron-Lynn G, Severson GM, Soules KA, Mueller AJ, Freeman WR. Cheng L, et al. Among authors: beadle jr. Invest Ophthalmol Vis Sci. 2000 May;41(6):1523-32. Invest Ophthalmol Vis Sci. 2000. PMID: 10798672

10

Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.

Hostetler KY, Beadle JR, Hornbuckle WE, Bellezza CA, Tochkov IA, Cote PJ, Gerin JL, Korba BE, Tennant BC. Hostetler KY, et al. Among authors: beadle jr. Antimicrob Agents Chemother. 2000 Jul;44(7):1964-9. doi: 10.1128/AAC.44.7.1964-1969.2000. Antimicrob Agents Chemother. 2000. PMID: 10858362 Free PMC article.

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