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Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
Beadle JR, Valiaeva N, Yang G, Yu JH, Broker TR, Aldern KA, Harden EA, Keith KA, Prichard MN, Hartman T, Buckheit RW Jr, Chow LT, Hostetler KY. Beadle JR, et al. Among authors: hartman t. J Med Chem. 2016 Dec 8;59(23):10470-10478. doi: 10.1021/acs.jmedchem.6b00659. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933957
Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy.
Hoshi A, Sakamoto T, Takayama J, Xuan M, Okazaki M, Hartman TL, Buckheit RW Jr, Pannecouque C, Cushman M. Hoshi A, et al. Among authors: hartman tl. Bioorg Med Chem. 2016 Jul 1;24(13):3006-3022. doi: 10.1016/j.bmc.2016.05.010. Epub 2016 May 24. Bioorg Med Chem. 2016. PMID: 27234889
The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target.
Nikolayevskiy H, Robello M, Scerba MT, Pasternak EH, Saha M, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH. Nikolayevskiy H, et al. Among authors: hartman tl. Eur J Med Chem. 2019 Sep 15;178:818-837. doi: 10.1016/j.ejmech.2019.06.020. Epub 2019 Jun 9. Eur J Med Chem. 2019. PMID: 31252286 Free PMC article.
745 results