Sirota M - Search Results

1

Synergistic drug combinations from electronic health records and gene expression.

Low YS, Daugherty AC, Schroeder EA, Chen W, Seto T, Weber S, Lim M, Hastie T, Mathur M, Desai M, Farrington C, Radin AA, Sirota M, Kenkare P, Thompson CA, Yu PP, Gomez SL, Sledge GW Jr, Kurian AW, Shah NH. Low YS, et al. Among authors: sirota m. J Am Med Inform Assoc. 2017 May 1;24(3):565-576. doi: 10.1093/jamia/ocw161. J Am Med Inform Assoc. 2017. PMID: 27940607 Free PMC article.

2

Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ. Sirota M, et al. Sci Transl Med. 2011 Aug 17;3(96):96ra77. doi: 10.1126/scitranslmed.3001318. Sci Transl Med. 2011. PMID: 21849665 Free PMC article.

3

Drug discovery in a multidimensional world: systems, patterns, and networks.

Dudley JT, Schadt E, Sirota M, Butte AJ, Ashley E. Dudley JT, et al. Among authors: sirota m. J Cardiovasc Transl Res. 2010 Oct;3(5):438-47. doi: 10.1007/s12265-010-9214-6. Epub 2010 Jul 31. J Cardiovasc Transl Res. 2010. PMID: 20677029

4

Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants.

Bagley SC, Sirota M, Chen R, Butte AJ, Altman RB. Bagley SC, et al. Among authors: sirota m. PLoS Comput Biol. 2016 Apr 26;12(4):e1004885. doi: 10.1371/journal.pcbi.1004885. eCollection 2016 Apr. PLoS Comput Biol. 2016. PMID: 27115429 Free PMC article.

5

Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses.

Paik H, Chen B, Sirota M, Hadley D, Butte AJ. Paik H, et al. Among authors: sirota m. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):599-607. doi: 10.1002/psp4.12108. Epub 2016 Nov 14. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27860440 Free PMC article.

6

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets.

Chen B, Ma L, Paik H, Sirota M, Wei W, Chua MS, So S, Butte AJ. Chen B, et al. Among authors: sirota m. Nat Commun. 2017 Jul 12;8:16022. doi: 10.1038/ncomms16022. Nat Commun. 2017. PMID: 28699633 Free PMC article.

7

Electronic Medical Records Enable Precision Medicine Approaches for Celiac Disease.

Kosti I, Sirota M. Kosti I, et al. Among authors: sirota m. J Pediatr Gastroenterol Nutr. 2018 Oct;67(4):434-435. doi: 10.1097/MPG.0000000000002021. J Pediatr Gastroenterol Nutr. 2018. PMID: 29746345 Free PMC article. No abstract available.

8

Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth.

Abraham A, Le B, Kosti I, Straub P, Velez-Edwards DR, Davis LK, Newton JM, Muglia LJ, Rokas A, Bejan CA, Sirota M, Capra JA. Abraham A, et al. Among authors: sirota m. BMC Med. 2022 Sep 28;20(1):333. doi: 10.1186/s12916-022-02522-x. BMC Med. 2022. PMID: 36167547 Free PMC article.

9

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes.

Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ. Kodama K, et al. Among authors: sirota m. Proc Natl Acad Sci U S A. 2012 May 1;109(18):7049-54. doi: 10.1073/pnas.1114513109. Epub 2012 Apr 12. Proc Natl Acad Sci U S A. 2012. PMID: 22499789 Free PMC article.

10

Systematic pan-cancer analysis of tumour purity.

Aran D, Sirota M, Butte AJ. Aran D, et al. Among authors: sirota m. Nat Commun. 2015 Dec 4;6:8971. doi: 10.1038/ncomms9971. Nat Commun. 2015. PMID: 26634437 Free PMC article.

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