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Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment.
Yang J, Savvatis K, Kang JS, Fan P, Zhong H, Schwartz K, Barry V, Mikels-Vigdal A, Karpinski S, Kornyeyev D, Adamkewicz J, Feng X, Zhou Q, Shang C, Kumar P, Phan D, Kasner M, López B, Diez J, Wright KC, Kovacs RL, Chen PS, Quertermous T, Smith V, Yao L, Tschöpe C, Chang CP. Yang J, et al. Among authors: smith v. Nat Commun. 2016 Dec 14;7:13710. doi: 10.1038/ncomms13710. Nat Commun. 2016. PMID: 27966531 Free PMC article.
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.
Pollheimer MJ, Racedo S, Mikels-Vigdal A, Marshall D, Bowlus C, Lackner C, Madl T, Karlsen TH, Hov JR, Lyman SK, Adamkewicz J, Smith V, Moreau E, Zollner G, Eide TJ, Stojakovic T, Scharnagl H, Gruber HJ, Stauber RE, Trauner M, Fickert P. Pollheimer MJ, et al. Among authors: smith v. J Hepatol. 2018 Aug;69(2):368-377. doi: 10.1016/j.jhep.2018.04.009. Epub 2018 Apr 28. J Hepatol. 2018. PMID: 29709678
Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.
Marshall DC, Lyman SK, McCauley S, Kovalenko M, Spangler R, Liu C, Lee M, O'Sullivan C, Barry-Hamilton V, Ghermazien H, Mikels-Vigdal A, Garcia CA, Jorgensen B, Velayo AC, Wang R, Adamkewicz JI, Smith V. Marshall DC, et al. Among authors: smith v. PLoS One. 2015 May 11;10(5):e0127063. doi: 10.1371/journal.pone.0127063. eCollection 2015. PLoS One. 2015. PMID: 25961845 Free PMC article.
MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors.
Juric V, O'Sullivan C, Stefanutti E, Kovalenko M, Greenstein A, Barry-Hamilton V, Mikaelian I, Degenhardt J, Yue P, Smith V, Mikels-Vigdal A. Juric V, et al. Among authors: smith v. PLoS One. 2018 Nov 30;13(11):e0207255. doi: 10.1371/journal.pone.0207255. eCollection 2018. PLoS One. 2018. PMID: 30500835 Free PMC article.
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.
Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, Oyasu M, Mikels A, Vaysberg M, Ghermazien H, Wai C, Garcia CA, Velayo AC, Jorgensen B, Biermann D, Tsai D, Green J, Zaffryar-Eilot S, Holzer A, Ogg S, Thai D, Neufeld G, Van Vlasselaer P, Smith V. Barry-Hamilton V, et al. Among authors: smith v. Nat Med. 2010 Sep;16(9):1009-17. doi: 10.1038/nm.2208. Epub 2010 Sep 5. Nat Med. 2010. PMID: 20818376
2,777 results