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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Lingel A, Sendzik M, Huang Y, Shultz MD, Cantwell J, Dillon MP, Fu X, Fuller J, Gabriel T, Gu J, Jiang X, Li L, Liang F, McKenna M, Qi W, Rao W, Sheng X, Shu W, Sutton J, Taft B, Wang L, Zeng J, Zhang H, Zhang M, Zhao K, Lindvall M, Bussiere DE. Lingel A, et al. Among authors: sheng x. J Med Chem. 2017 Jan 12;60(1):415-427. doi: 10.1021/acs.jmedchem.6b01473. Epub 2017 Jan 3. J Med Chem. 2017. PMID: 27992714
Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor.
Zhang X, Sheng X, Shen J, Zhang S, Sun W, Shen C, Li Y, Wang J, Lv H, Cui M, Zhu Y, Huang L, Hao D, Qi Z, Sun G, Mao W, Pan Y, Shen L, Li X, Hu G, Gong Z, Han S, Li J, Chen S, Tu R, Wang X, Wu C. Zhang X, et al. Among authors: sheng x. ACS Med Chem Lett. 2019 Dec 11;11(10):1863-1868. doi: 10.1021/acsmedchemlett.9b00395. eCollection 2020 Oct 8. ACS Med Chem Lett. 2019. PMID: 33062165 Free PMC article.
2,755 results