Liu X - Search Results

1

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.

Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. Liu X, et al. Structure. 2016 Dec 6;24(12):2053-2066. doi: 10.1016/j.str.2016.08.019. Epub 2016 Oct 27. Structure. 2016. PMID: 27998539 Free PMC article.

2

The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. Shepherd TR, et al. Among authors: liu x. J Mol Biol. 2010 May 21;398(5):730-46. doi: 10.1016/j.jmb.2010.03.047. Epub 2010 Mar 31. J Mol Biol. 2010. PMID: 20361982 Free PMC article.

3

The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.

Liu X, Shepherd TR, Murray AM, Xu Z, Fuentes EJ. Liu X, et al. Structure. 2013 Mar 5;21(3):342-54. doi: 10.1016/j.str.2013.01.004. Epub 2013 Feb 7. Structure. 2013. PMID: 23395182 Free PMC article.

4

Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.

Liu X, Fuentes EJ. Liu X, et al. Int Rev Cell Mol Biol. 2019;343:129-218. doi: 10.1016/bs.ircmb.2018.05.013. Epub 2018 Jun 28. Int Rev Cell Mol Biol. 2019. PMID: 30712672 Free PMC article. Review.

5

Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction.

Liu X, Golden LC, Lopez JA, Shepherd TR, Yu L, Fuentes EJ. Liu X, et al. Biophys J. 2019 Jun 18;116(12):2314-2330. doi: 10.1016/j.bpj.2019.05.008. Epub 2019 May 11. Biophys J. 2019. PMID: 31146922 Free PMC article.

6

First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids.

Liu X, Wang Y, Ortlund EA. Liu X, et al. Mol Pharmacol. 2019 Oct;96(4):408-417. doi: 10.1124/mol.119.116806. Epub 2019 Aug 7. Mol Pharmacol. 2019. PMID: 31391291 Free PMC article.

7

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.

Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X. Horton JR, et al. Among authors: liu x. Cell Chem Biol. 2016 Jul 21;23(7):769-781. doi: 10.1016/j.chembiol.2016.06.006. Epub 2016 Jul 14. Cell Chem Biol. 2016. PMID: 27427228 Free PMC article.

8

The nuclear receptor superfamily: A structural perspective.

Weikum ER, Liu X, Ortlund EA. Weikum ER, et al. Among authors: liu x. Protein Sci. 2018 Nov;27(11):1876-1892. doi: 10.1002/pro.3496. Protein Sci. 2018. PMID: 30109749 Free PMC article. Review.

9

Structural insights into glucocorticoid receptor function.

Frank F, Ortlund EA, Liu X. Frank F, et al. Among authors: liu x. Biochem Soc Trans. 2021 Nov 1;49(5):2333-2343. doi: 10.1042/BST20210419. Biochem Soc Trans. 2021. PMID: 34709368 Free PMC article. Review.

10

A phospholipid mimetic targeting LRH-1 ameliorates colitis.

Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel A, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, Jui NT, Ortlund EA. Mays SG, et al. Among authors: liu x. Cell Chem Biol. 2022 Jul 21;29(7):1174-1186.e7. doi: 10.1016/j.chembiol.2022.03.001. Epub 2022 Mar 21. Cell Chem Biol. 2022. PMID: 35316658 Free article.

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