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Page 1
Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score.
Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A. Hachiya T, et al. Among authors: sobue k. Stroke. 2017 Feb;48(2):253-258. doi: 10.1161/STROKEAHA.116.014506. Epub 2016 Dec 29. Stroke. 2017. PMID: 28034966 Free PMC article.
Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes.
Takahashi Y, Ueki M, Tamiya G, Ogishima S, Kinoshita K, Hozawa A, Minegishi N, Nagami F, Fukumoto K, Otsuka K, Tanno K, Sakata K, Shimizu A, Sasaki M, Sobue K, Kure S, Yamamoto M, Tomita H. Takahashi Y, et al. Among authors: sobue k. Transl Psychiatry. 2020 Aug 17;10(1):294. doi: 10.1038/s41398-020-00957-5. Transl Psychiatry. 2020. PMID: 32826857 Free PMC article.
Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population.
Kotozaki Y, Satoh M, Tanno K, Ohmomo H, Otomo R, Tanaka F, Nasu T, Taguchi S, Kikuchi H, Kobayashi T, Shimizu A, Sakata K, Hitomi J, Sobue K, Sasaki M. Kotozaki Y, et al. Among authors: sobue k. Int J Environ Res Public Health. 2021 Feb 16;18(4):1894. doi: 10.3390/ijerph18041894. Int J Environ Res Public Health. 2021. PMID: 33669298 Free PMC article.
Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.
Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, Hata J, Hozawa A, Iwasaki M, Matsuda K, Minegishi N, Satoh M, Tanno K, Yamaji T, Wakai K, Hitomi J, Kiyohara Y, Kubo M, Tanaka H, Tsugane S, Yamamoto M, Sobue K, Shimizu A. Shiwa Y, et al. Among authors: sobue k. PLoS One. 2016 Jan 22;11(1):e0147519. doi: 10.1371/journal.pone.0147519. eCollection 2016. PLoS One. 2016. PMID: 26799745 Free PMC article.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Sc… See abstract for full author list ➔ Malik R, et al. Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12. Nat Genet. 2018. PMID: 29531354 Free PMC article.
The Value of a Cystatin C-based Estimated Glomerular Filtration Rate for Cardiovascular Assessment in a General Japanese Population: Results From the Iwate Tohoku Medical Megabank Project.
Osaki T, Satoh M, Tanaka F, Tanno K, Takahashi Y, Nasu T, Sakata K, Morino Y, Sobue K, Sasaki M. Osaki T, et al. Among authors: sobue k. J Epidemiol. 2020 Jun 5;30(6):260-267. doi: 10.2188/jea.JE20180274. Epub 2019 May 25. J Epidemiol. 2020. PMID: 31130557 Free PMC article.
A genome-wide association study for highly sensitive cardiac troponin T levels identified a novel genetic variation near a RBAK-ZNF890P locus in the Japanese general population.
Nasu T, Satoh M, Hachiya T, Sutoh Y, Ohmomo H, Hitomi S, Taguchi S, Kikuchi H, Kobayashi T, Takahashi Y, Osaki T, Morino Y, Sobue K, Shimizu A, Sasaki M. Nasu T, et al. Among authors: sobue k. Int J Cardiol. 2021 Apr 15;329:186-191. doi: 10.1016/j.ijcard.2020.12.019. Epub 2020 Dec 13. Int J Cardiol. 2021. PMID: 33321125
Association between total type I collagen N-terminal propeptide and coronary artery disease risk score in the general Japanese population.
Kikuchi H, Nasu T, Satoh M, Kotozaki Y, Tanno K, Asahi K, Ohmomo H, Kobayashi T, Taguchi S, Morino Y, Shimizu A, Sobue K, Sasaki M. Kikuchi H, et al. Among authors: sobue k. Int J Cardiol Heart Vasc. 2022 May 19;41:101056. doi: 10.1016/j.ijcha.2022.101056. eCollection 2022 Aug. Int J Cardiol Heart Vasc. 2022. PMID: 35620659 Free PMC article.
Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Sh… See abstract for full author list ➔ Mishra A, et al. Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3. Epub 2022 Sep 30. Nature. 2022. PMID: 36180795 Free PMC article.
348 results