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Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR. Ghosh A, et al. Among authors: dudakov ja. Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9. Nat Med. 2017. PMID: 28067900 Free PMC article.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR. Hanash AM, et al. Among authors: dudakov ja. Immunity. 2012 Aug 24;37(2):339-50. doi: 10.1016/j.immuni.2012.05.028. Immunity. 2012. PMID: 22921121 Free PMC article.
The central nervous system is a target of acute graft versus host disease in mice.
Hartrampf S, Dudakov JA, Johnson LK, Smith OM, Tsai J, Singer NV, West ML, Hanash AM, Albert MH, Liu B, Toth M, van den Brink MR. Hartrampf S, et al. Among authors: dudakov ja. Blood. 2013 Mar 7;121(10):1906-10. doi: 10.1182/blood-2012-09-456590. Epub 2013 Jan 8. Blood. 2013. PMID: 23299314 Free PMC article.
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM. Lindemans CA, et al. Among authors: dudakov ja. Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9. Nature. 2015. PMID: 26649819 Free PMC article.
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR. Shono Y, et al. Among authors: dudakov ja. Sci Transl Med. 2016 May 18;8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311. Sci Transl Med. 2016. PMID: 27194729 Free PMC article.
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.
Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA. Velardi E, et al. Among authors: dudakov ja. Nat Med. 2018 Feb;24(2):239-246. doi: 10.1038/nm.4470. Epub 2018 Jan 8. Nat Med. 2018. PMID: 29309056 Free PMC article.
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM. Tsai JJ, et al. Among authors: dudakov ja. Blood. 2018 Dec 27;132(26):2763-2774. doi: 10.1182/blood-2017-10-812941. Epub 2018 Oct 31. Blood. 2018. PMID: 30381375 Free PMC article.
48 results