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410 results

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Page 1
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR. Ghosh A, et al. Among authors: murphy gf. Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9. Nat Med. 2017. PMID: 28067900 Free PMC article.
NOD2 regulates hematopoietic cell function during graft-versus-host disease.
Penack O, Smith OM, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Brandl K, van den Brink MR. Penack O, et al. Among authors: murphy gf. J Exp Med. 2009 Sep 28;206(10):2101-10. doi: 10.1084/jem.20090623. Epub 2009 Sep 8. J Exp Med. 2009. PMID: 19737867 Free PMC article.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR. Hanash AM, et al. Among authors: murphy gf. Immunity. 2012 Aug 24;37(2):339-50. doi: 10.1016/j.immuni.2012.05.028. Immunity. 2012. PMID: 22921121 Free PMC article.
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity.
Ghosh A, Dogan Y, Moroz M, Holland AM, Yim NL, Rao UK, Young LF, Tannenbaum D, Masih D, Velardi E, Tsai JJ, Jenq RR, Penack O, Hanash AM, Smith OM, Piersanti K, Lezcano C, Murphy GF, Liu C, Palomba ML, Sauer MG, Sadelain M, Ponomarev V, van den Brink MR. Ghosh A, et al. Among authors: murphy gf. J Clin Invest. 2013 Jun;123(6):2654-62. doi: 10.1172/JCI66301. Epub 2013 May 15. J Clin Invest. 2013. PMID: 23676461 Free PMC article.
PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD.
Ghosh A, Holland AM, Dogan Y, Yim NL, Rao UK, Young LF, West ML, Singer NV, Lee H, Na IK, Tsai JJ, Jenq RR, Penack O, Hanash AM, Lezcano C, Murphy GF, Liu C, Sadelain M, Sauer MG, Sant'angelo D, van den Brink MR. Ghosh A, et al. Among authors: murphy gf. Cancer Res. 2013 Aug 1;73(15):4687-96. doi: 10.1158/0008-5472.CAN-12-4699. Epub 2013 Jun 3. Cancer Res. 2013. PMID: 23733752 Free PMC article.
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR. Shono Y, et al. Among authors: murphy gf. Sci Transl Med. 2016 May 18;8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311. Sci Transl Med. 2016. PMID: 27194729 Free PMC article.
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM. Tsai JJ, et al. Among authors: murphy gf. Blood. 2018 Dec 27;132(26):2763-2774. doi: 10.1182/blood-2017-10-812941. Epub 2018 Oct 31. Blood. 2018. PMID: 30381375 Free PMC article.
T cells require TRAIL for optimal graft-versus-tumor activity.
Schmaltz C, Alpdogan O, Kappel BJ, Muriglan SJ, Rotolo JA, Ongchin J, Willis LM, Greenberg AS, Eng JM, Crawford JM, Murphy GF, Yagita H, Walczak H, Peschon JJ, van den Brink MR. Schmaltz C, et al. Among authors: murphy gf. Nat Med. 2002 Dec;8(12):1433-7. doi: 10.1038/nm1202-797. Epub 2002 Nov 11. Nat Med. 2002. PMID: 12426560
Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation.
Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Muriglan SJ, Kochman AA, Terwey TH, Willis LM, Schiro R, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR. Hubbard VM, et al. Among authors: murphy gf. Blood. 2005 Nov 1;106(9):3285-92. doi: 10.1182/blood-2005-01-0410. Epub 2005 Jun 14. Blood. 2005. PMID: 15956289 Free PMC article.
CCR2 is required for CD8-induced graft-versus-host disease.
Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-Montagut T, Eng JM, Muriglan SJ, Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MR. Terwey TH, et al. Among authors: murphy gf. Blood. 2005 Nov 1;106(9):3322-30. doi: 10.1182/blood-2005-05-1860. Epub 2005 Jul 21. Blood. 2005. PMID: 16037386 Free PMC article.
410 results