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Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR. Ghosh A, et al. Among authors: tuckett az. Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9. Nat Med. 2017. PMID: 28067900 Free PMC article.
A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.
Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL. Shono Y, et al. Among authors: tuckett az. Cancer Discov. 2014 May;4(5):578-91. doi: 10.1158/2159-8290.CD-13-0585. Epub 2014 Feb 18. Cancer Discov. 2014. PMID: 24550032 Free PMC article.
Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.
Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MR. Velardi E, et al. Among authors: tuckett az. J Exp Med. 2014 Nov 17;211(12):2341-9. doi: 10.1084/jem.20131289. Epub 2014 Oct 20. J Exp Med. 2014. PMID: 25332287 Free PMC article.
Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses.
Shono Y, Tuckett AZ, Liou HC, Doubrovina E, Derenzini E, Ouk S, Tsai JJ, Smith OM, Levy ER, Kreines FM, Ziegler CG, Scallion MI, Doubrovin M, Heller G, Younes A, O'Reilly RJ, van den Brink MR, Zakrzewski JL. Shono Y, et al. Among authors: tuckett az. Cancer Res. 2016 Jan 15;76(2):377-89. doi: 10.1158/0008-5472.CAN-14-2814. Epub 2016 Jan 7. Cancer Res. 2016. PMID: 26744524 Free PMC article.
Transforming lymph nodes into tissue factories.
Zakrzewski JL, Tuckett AZ, van den Brink MR. Zakrzewski JL, et al. Among authors: tuckett az. Nat Biotechnol. 2012 Oct;30(10):958-9. doi: 10.1038/nbt.2388. Nat Biotechnol. 2012. PMID: 23051813 No abstract available.
11 results