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Page 1
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.
McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue CA, Feinberg AP. McDonald OG, et al. Among authors: wellen ke. Nat Genet. 2017 Mar;49(3):367-376. doi: 10.1038/ng.3753. Epub 2017 Jan 16. Nat Genet. 2017. PMID: 28092686 Free PMC article.
IDH mutation impairs histone demethylation and results in a block to cell differentiation.
Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. Lu C, et al. Among authors: wellen ke. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860. Nature. 2012. PMID: 22343901 Free PMC article.
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE. Lee JV, et al. Among authors: wellen ke. Cell Metab. 2014 Aug 5;20(2):306-319. doi: 10.1016/j.cmet.2014.06.004. Epub 2014 Jul 3. Cell Metab. 2014. PMID: 24998913 Free PMC article.
Metabolism and epigenetics: a link cancer cells exploit.
Carrer A, Wellen KE. Carrer A, et al. Among authors: wellen ke. Curr Opin Biotechnol. 2015 Aug;34:23-9. doi: 10.1016/j.copbio.2014.11.012. Epub 2014 Nov 29. Curr Opin Biotechnol. 2015. PMID: 25461508 Free PMC article. Review.
Molecular biology: Salvaging the genome.
Sivanand S, Wellen KE. Sivanand S, et al. Among authors: wellen ke. Nature. 2015 Aug 6;524(7563):40-1. doi: 10.1038/nature14638. Epub 2015 Jul 22. Nature. 2015. PMID: 26200344 No abstract available.
Dysregulated metabolism contributes to oncogenesis.
Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team. Hirschey MD, et al. Among authors: wellen ke. Semin Cancer Biol. 2015 Dec;35 Suppl:S129-S150. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8. Semin Cancer Biol. 2015. PMID: 26454069 Free PMC article. Review.
Designing a broad-spectrum integrative approach for cancer prevention and treatment.
Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Moha… See abstract for full author list ➔ Block KI, et al. Among authors: wellen ke. Semin Cancer Biol. 2015 Dec;35 Suppl(Suppl):S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Semin Cancer Biol. 2015. PMID: 26590477 Free PMC article. Review.
A cancerous web: signaling, metabolism, and the epigenome.
Lee JV, Shah S, Carrer A, Wellen KE. Lee JV, et al. Among authors: wellen ke. Mol Cell Oncol. 2014 Oct 30;2(2):e965620. doi: 10.4161/23723548.2014.965620. eCollection 2015 Apr-Jun. Mol Cell Oncol. 2014. PMID: 27308412 Free PMC article.
Metabolic control of epigenetics in cancer.
Kinnaird A, Zhao S, Wellen KE, Michelakis ED. Kinnaird A, et al. Among authors: wellen ke. Nat Rev Cancer. 2016 Nov;16(11):694-707. doi: 10.1038/nrc.2016.82. Epub 2016 Sep 16. Nat Rev Cancer. 2016. PMID: 27634449 Review.
Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels.
Carrer A, Parris JLD, Trefely S, Henry RA, Montgomery DC, Torres A, Viola JM, Kuo YM, Blair IA, Meier JL, Andrews AJ, Snyder NW, Wellen KE. Carrer A, et al. Among authors: wellen ke. J Biol Chem. 2017 Feb 24;292(8):3312-3322. doi: 10.1074/jbc.M116.750620. Epub 2017 Jan 11. J Biol Chem. 2017. PMID: 28077572 Free PMC article.
84 results