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A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.
Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. Wrasidlo W, et al. Brain. 2016 Dec;139(Pt 12):3217-3236. doi: 10.1093/brain/aww238. Epub 2016 Sep 27. Brain. 2016. PMID: 27679481 Free PMC article.
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.
Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. Prots I, et al. Among authors: wrasidlo w. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818. doi: 10.1073/pnas.1713129115. Epub 2018 Jul 10. Proc Natl Acad Sci U S A. 2018. PMID: 29991596 Free PMC article.
Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.
Kouroupi G, Taoufik E, Vlachos IS, Tsioras K, Antoniou N, Papastefanaki F, Chroni-Tzartou D, Wrasidlo W, Bohl D, Stellas D, Politis PK, Vekrellis K, Papadimitriou D, Stefanis L, Bregestovski P, Hatzigeorgiou AG, Masliah E, Matsas R. Kouroupi G, et al. Among authors: wrasidlo w. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3679-E3688. doi: 10.1073/pnas.1617259114. Epub 2017 Apr 17. Proc Natl Acad Sci U S A. 2017. PMID: 28416701 Free PMC article.
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.
Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. Murphy EA, et al. Among authors: wrasidlo w. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4299-304. doi: 10.1073/pnas.0909299107. Epub 2010 Feb 12. Proc Natl Acad Sci U S A. 2010. PMID: 20154271 Free PMC article.
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis.
Murphy EA, Majeti BK, Barnes LA, Makale M, Weis SM, Lutu-Fuga K, Wrasidlo W, Cheresh DA. Murphy EA, et al. Among authors: wrasidlo w. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9343-8. doi: 10.1073/pnas.0803728105. Epub 2008 Jul 7. Proc Natl Acad Sci U S A. 2008. PMID: 18607000 Free PMC article.
62 results