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Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.
Brown DA, Mishra M, Zhang S, Biswas S, Parrington I, Antonio T, Reith ME, Dutta AK. Brown DA, et al. Among authors: antonio t. Bioorg Med Chem. 2009 Jun 1;17(11):3923-33. doi: 10.1016/j.bmc.2009.04.031. Epub 2009 Apr 19. Bioorg Med Chem. 2009. PMID: 19427222 Free PMC article.
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease.
Ghosh B, Antonio T, Reith ME, Dutta AK. Ghosh B, et al. Among authors: antonio t. J Med Chem. 2010 Mar 11;53(5):2114-25. doi: 10.1021/jm901618d. J Med Chem. 2010. PMID: 20146482 Free PMC article.
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.
Ghosh B, Antonio T, Gopishetty B, Reith M, Dutta A. Ghosh B, et al. Among authors: antonio t. Bioorg Med Chem. 2010 Aug 1;18(15):5661-74. doi: 10.1016/j.bmc.2010.06.025. Epub 2010 Jun 12. Bioorg Med Chem. 2010. PMID: 20605099 Free PMC article.
Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization.
Johnson M, Antonio T, Reith ME, Dutta AK. Johnson M, et al. Among authors: antonio t. J Med Chem. 2012 Jun 28;55(12):5826-40. doi: 10.1021/jm300268s. Epub 2012 Jun 13. J Med Chem. 2012. PMID: 22642365 Free PMC article.
58 results