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Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.
Gopishetty B, Zhang S, Kharkar PS, Antonio T, Reith M, Dutta AK. Gopishetty B, et al. Bioorg Med Chem. 2013 Jun 1;21(11):3164-74. doi: 10.1016/j.bmc.2013.03.059. Epub 2013 Apr 1. Bioorg Med Chem. 2013. PMID: 23623679 Free PMC article.
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease.
Ghosh B, Antonio T, Reith ME, Dutta AK. Ghosh B, et al. J Med Chem. 2010 Mar 11;53(5):2114-25. doi: 10.1021/jm901618d. J Med Chem. 2010. PMID: 20146482 Free PMC article.
Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization.
Johnson M, Antonio T, Reith ME, Dutta AK. Johnson M, et al. J Med Chem. 2012 Jun 28;55(12):5826-40. doi: 10.1021/jm300268s. Epub 2012 Jun 13. J Med Chem. 2012. PMID: 22642365 Free PMC article.
Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease.
Das B, Vedachalam S, Luo D, Antonio T, Reith ME, Dutta AK. Das B, et al. J Med Chem. 2015 Dec 10;58(23):9179-95. doi: 10.1021/acs.jmedchem.5b01031. Epub 2015 Nov 30. J Med Chem. 2015. PMID: 26555041 Free PMC article.
264 results