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Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS. Iyer SS, et al. Among authors: sutterwala fs. Immunity. 2013 Aug 22;39(2):311-323. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15. Immunity. 2013. PMID: 23954133 Free PMC article.
Mechanism of NLRP3 inflammasome activation.
Sutterwala FS, Haasken S, Cassel SL. Sutterwala FS, et al. Ann N Y Acad Sci. 2014 Jun;1319(1):82-95. doi: 10.1111/nyas.12458. Epub 2014 May 19. Ann N Y Acad Sci. 2014. PMID: 24840700 Free PMC article. Review.
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Iyer SS, et al. Among authors: sutterwala fs. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20388-93. doi: 10.1073/pnas.0908698106. Epub 2009 Nov 16. Proc Natl Acad Sci U S A. 2009. PMID: 19918053 Free PMC article.
Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation.
Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M. Dagvadorj J, et al. Among authors: sutterwala fs. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015632118. doi: 10.1073/pnas.2015632118. Proc Natl Acad Sci U S A. 2021. PMID: 33361152 Free PMC article.
Monocytes Take Their Own Path to IL-1β.
Elliott EI, Sutterwala FS. Elliott EI, et al. Among authors: sutterwala fs. Immunity. 2016 Apr 19;44(4):713-5. doi: 10.1016/j.immuni.2016.03.015. Immunity. 2016. PMID: 27096310 Free article.
114 results