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The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection.
Lin PL, Dietrich J, Tan E, Abalos RM, Burgos J, Bigbee C, Bigbee M, Milk L, Gideon HP, Rodgers M, Cochran C, Guinn KM, Sherman DR, Klein E, Janssen C, Flynn JL, Andersen P. Lin PL, et al. Among authors: rodgers m. J Clin Invest. 2012 Jan;122(1):303-14. doi: 10.1172/JCI46252. Epub 2011 Dec 1. J Clin Invest. 2012. PMID: 22133873 Free PMC article.
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.
Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL. Gideon HP, et al. Among authors: rodgers ma. PLoS Pathog. 2015 Jan 22;11(1):e1004603. doi: 10.1371/journal.ppat.1004603. eCollection 2015 Jan. PLoS Pathog. 2015. PMID: 25611466 Free PMC article.
The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans.
Mothé BR, Lindestam Arlehamn CS, Dow C, Dillon MBC, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, O'Connor DH, Sette A. Mothé BR, et al. Tuberculosis (Edinb). 2015 Dec;95(6):722-735. doi: 10.1016/j.tube.2015.07.005. Epub 2015 Aug 28. Tuberculosis (Edinb). 2015. PMID: 26526557 Free PMC article.
PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis.
Lin PL, Maiello P, Gideon HP, Coleman MT, Cadena AM, Rodgers MA, Gregg R, O'Malley M, Tomko J, Fillmore D, Frye LJ, Rutledge T, DiFazio RM, Janssen C, Klein E, Andersen PL, Fortune SM, Flynn JL. Lin PL, et al. Among authors: rodgers ma. PLoS Pathog. 2016 Jul 5;12(7):e1005739. doi: 10.1371/journal.ppat.1005739. eCollection 2016 Jul. PLoS Pathog. 2016. PMID: 27379816 Free PMC article.
Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques.
Darrah PA, DiFazio RM, Maiello P, Gideon HP, Myers AJ, Rodgers MA, Hackney JA, Lindenstrom T, Evans T, Scanga CA, Prikhodko V, Andersen P, Lin PL, Laddy D, Roederer M, Seder RA, Flynn JL. Darrah PA, et al. Among authors: rodgers ma. NPJ Vaccines. 2019 May 28;4:21. doi: 10.1038/s41541-019-0113-9. eCollection 2019. NPJ Vaccines. 2019. PMID: 31149352 Free PMC article.
Prevention of tuberculosis in macaques after intravenous BCG immunization.
Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH 2nd, Hughes TK, Pokkali S, Swanson PA 2nd, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, Lin PL, Klein E, White AG, Scanga CA, Shalek AK, Roederer M, Flynn JL, Seder RA. Darrah PA, et al. Among authors: rodgers ma. Nature. 2020 Jan;577(7788):95-102. doi: 10.1038/s41586-019-1817-8. Epub 2020 Jan 1. Nature. 2020. PMID: 31894150 Free PMC article.
748 results