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Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
Genome Biol. 2017 Jan 30;18(1):22. doi: 10.1186/s13059-017-1147-9.
Genome Biol. 2017.
PMID: 28137300
Free PMC article.
Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.
Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC.
Lechler MC, et al.
Cell Rep. 2017 Jan 10;18(2):454-467. doi: 10.1016/j.celrep.2016.12.033.
Cell Rep. 2017.
PMID: 28076789
Free PMC article.
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More stressed out with age? Check your RNA granule aggregation.
Lechler MC, David DC.
Lechler MC, et al.
Prion. 2017 Sep 3;11(5):313-322. doi: 10.1080/19336896.2017.1356559.
Prion. 2017.
PMID: 28956717
Free PMC article.
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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans.
Groh N, Gallotta I, Lechler MC, Huang C, Jung R, David DC.
Groh N, et al. Among authors: lechler mc.
J Vis Exp. 2017 Nov 26;(129):56464. doi: 10.3791/56464.
J Vis Exp. 2017.
PMID: 29286457
Free PMC article.
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Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.
Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC.
Huang C, et al. Among authors: lechler mc.
Elife. 2019 May 3;8:e43059. doi: 10.7554/eLife.43059.
Elife. 2019.
PMID: 31050339
Free PMC article.
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A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans.
Jung R, Lechler MC, Fernandez-Villegas A, Chung CW, Jones HC, Choi YH, Thompson MA, Rödelsperger C, Röseler W, Kaminski Schierle GS, Sommer RJ, David DC.
Jung R, et al. Among authors: lechler mc.
PLoS Biol. 2023 Sep 14;21(9):e3002284. doi: 10.1371/journal.pbio.3002284. eCollection 2023 Sep.
PLoS Biol. 2023.
PMID: 37708127
Free PMC article.
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