Mikkelsen TS - Search Results

1

Systematic dissection of genomic features determining transcription factor binding and enhancer function.

Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES. Grossman SR, et al. Among authors: mikkelsen ts. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1291-E1300. doi: 10.1073/pnas.1621150114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137873 Free PMC article.

2

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.

Melnikov A, Murugan A, Zhang X, Tesileanu T, Wang L, Rogov P, Feizi S, Gnirke A, Callan CG Jr, Kinney JB, Kellis M, Lander ES, Mikkelsen TS. Melnikov A, et al. Among authors: mikkelsen ts. Nat Biotechnol. 2012 Feb 26;30(3):271-7. doi: 10.1038/nbt.2137. Nat Biotechnol. 2012. PMID: 22371084 Free PMC article.

3

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.

Kheradpour P, Ernst J, Melnikov A, Rogov P, Wang L, Zhang X, Alston J, Mikkelsen TS, Kellis M. Kheradpour P, et al. Among authors: mikkelsen ts. Genome Res. 2013 May;23(5):800-11. doi: 10.1101/gr.144899.112. Epub 2013 Mar 19. Genome Res. 2013. PMID: 23512712 Free PMC article.

4

Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites.

Xie X, Mikkelsen TS, Gnirke A, Lindblad-Toh K, Kellis M, Lander ES. Xie X, et al. Among authors: mikkelsen ts. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7145-50. doi: 10.1073/pnas.0701811104. Epub 2007 Apr 18. Proc Natl Acad Sci U S A. 2007. PMID: 17442748 Free PMC article.

5

Dissecting direct reprogramming through integrative genomic analysis.

Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A. Mikkelsen TS, et al. Nature. 2008 Jul 3;454(7200):49-55. doi: 10.1038/nature07056. Epub 2008 May 28. Nature. 2008. PMID: 18509334 Free PMC article.

6

Comparative epigenomic analysis of murine and human adipogenesis.

Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED. Mikkelsen TS, et al. Cell. 2010 Oct 1;143(1):156-69. doi: 10.1016/j.cell.2010.09.006. Cell. 2010. PMID: 20887899 Free PMC article.

7

Mapping and analysis of chromatin state dynamics in nine human cell types.

Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE. Ernst J, et al. Among authors: mikkelsen ts. Nature. 2011 May 5;473(7345):43-9. doi: 10.1038/nature09906. Epub 2011 Mar 23. Nature. 2011. PMID: 21441907 Free PMC article.

8

Massively parallel reporter assays in cultured mammalian cells.

Melnikov A, Zhang X, Rogov P, Wang L, Mikkelsen TS. Melnikov A, et al. Among authors: mikkelsen ts. J Vis Exp. 2014 Aug 17;(90):51719. doi: 10.3791/51719. J Vis Exp. 2014. PMID: 25177895 Free PMC article.

9

Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits.

Ulirsch JC, Nandakumar SK, Wang L, Giani FC, Zhang X, Rogov P, Melnikov A, McDonel P, Do R, Mikkelsen TS, Sankaran VG. Ulirsch JC, et al. Among authors: mikkelsen ts. Cell. 2016 Jun 2;165(6):1530-1545. doi: 10.1016/j.cell.2016.04.048. Cell. 2016. PMID: 27259154 Free PMC article.

10

Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions.

Ernst J, Melnikov A, Zhang X, Wang L, Rogov P, Mikkelsen TS, Kellis M. Ernst J, et al. Among authors: mikkelsen ts. Nat Biotechnol. 2016 Nov;34(11):1180-1190. doi: 10.1038/nbt.3678. Epub 2016 Oct 3. Nat Biotechnol. 2016. PMID: 27701403 Free PMC article.

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