Sansom DM - Search Results

1

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.

Hou TZ, Verma N, Wanders J, Kennedy A, Soskic B, Janman D, Halliday N, Rowshanravan B, Worth A, Qasim W, Baxendale H, Stauss H, Seneviratne S, Neth O, Olbrich P, Hambleton S, Arkwright PD, Burns SO, Walker LS, Sansom DM. Hou TZ, et al. Among authors: sansom dm. Blood. 2017 Mar 16;129(11):1458-1468. doi: 10.1182/blood-2016-10-745174. Epub 2017 Feb 3. Blood. 2017. PMID: 28159733 Free PMC article.

2

Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80.

Boulougouris G, McLeod JD, Patel YI, Ellwood CN, Walker LS, Sansom DM. Boulougouris G, et al. Among authors: sansom dm. J Immunol. 1998 Oct 15;161(8):3919-24. J Immunol. 1998. PMID: 9780158

3

IL-2-independent activation and proliferation in human T cells induced by CD28.

Boulougouris G, McLeod JD, Patel YI, Ellwood CN, Walker LS, Sansom DM. Boulougouris G, et al. Among authors: sansom dm. J Immunol. 1999 Aug 15;163(4):1809-16. J Immunol. 1999. PMID: 10438913

4

CTLA4 gene polymorphism and autoimmunity.

Gough SC, Walker LS, Sansom DM. Gough SC, et al. Among authors: sansom dm. Immunol Rev. 2005 Apr;204:102-15. doi: 10.1111/j.0105-2896.2005.00249.x. Immunol Rev. 2005. PMID: 15790353 Review.

5

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology.

Sansom DM, Walker LS. Sansom DM, et al. Immunol Rev. 2006 Aug;212:131-48. doi: 10.1111/j.0105-2896.2006.00419.x. Immunol Rev. 2006. PMID: 16903911 Review.

6

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.

Zheng Y, Manzotti CN, Burke F, Dussably L, Qureshi O, Walker LS, Sansom DM. Zheng Y, et al. Among authors: sansom dm. J Immunol. 2008 Aug 1;181(3):1683-91. doi: 10.4049/jimmunol.181.3.1683. J Immunol. 2008. PMID: 18641304 Free PMC article.

7

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.

Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS. Schmidt EM, et al. Among authors: sansom dm. J Immunol. 2009 Jan 1;182(1):274-82. doi: 10.4049/jimmunol.182.1.274. J Immunol. 2009. PMID: 19109158

8

1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, Walker LS, Lammas DA, Raza K, Sansom DM. Jeffery LE, et al. Among authors: sansom dm. J Immunol. 2009 Nov 1;183(9):5458-67. doi: 10.4049/jimmunol.0803217. J Immunol. 2009. PMID: 19843932 Free PMC article.

9

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM. Qureshi OS, et al. Among authors: sansom dm. Science. 2011 Apr 29;332(6029):600-3. doi: 10.1126/science.1202947. Epub 2011 Apr 7. Science. 2011. PMID: 21474713 Free PMC article.

10

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.

Walker LS, Sansom DM. Walker LS, et al. Among authors: sansom dm. Nat Rev Immunol. 2011 Nov 25;11(12):852-63. doi: 10.1038/nri3108. Nat Rev Immunol. 2011. PMID: 22116087

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