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Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.
Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Zhang S, et al. J Hepatol. 2017 Dec;67(6):1194-1203. doi: 10.1016/j.jhep.2017.07.006. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733220 Free PMC article.
Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.
Song X, Liu X, Wang H, Wang J, Qiao Y, Cigliano A, Utpatel K, Ribback S, Pilo MG, Serra M, Gordan JD, Che L, Zhang S, Cossu A, Porcu A, Pascale RM, Dombrowski F, Hu H, Calvisi DF, Evert M, Chen X. Song X, et al. Among authors: zhang s. Clin Cancer Res. 2019 Jan 1;25(1):403-413. doi: 10.1158/1078-0432.CCR-18-0284. Epub 2018 Jul 3. Clin Cancer Res. 2019. PMID: 30084835 Free PMC article.
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease.
Cigliano A, Zhang S, Ribback S, Steinmann S, Sini M, Ament CE, Utpatel K, Song X, Wang J, Pilo MG, Berger F, Wang H, Tao J, Li X, Pes GM, Mancarella S, Giannelli G, Dombrowski F, Evert M, Calvisi DF, Chen X, Evert K. Cigliano A, et al. Among authors: zhang s. J Exp Clin Cancer Res. 2022 Jun 3;41(1):192. doi: 10.1186/s13046-022-02394-2. J Exp Clin Cancer Res. 2022. PMID: 35655220 Free PMC article.
Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
Dong M, Liu X, Evert K, Utpatel K, Peters M, Zhang S, Xu Z, Che L, Cigliano A, Ribback S, Dombrowski F, Cossu A, Gordan J, Calvisi DF, Evert M, Liu Y, Chen X. Dong M, et al. Among authors: zhang s. Cell Death Dis. 2018 Jan 18;9(2):31. doi: 10.1038/s41419-017-0183-4. Cell Death Dis. 2018. PMID: 29348467 Free PMC article.
Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.
Zhang S, Wang J, Wang H, Fan L, Fan B, Zeng B, Tao J, Li X, Che L, Cigliano A, Ribback S, Dombrowski F, Chen B, Cong W, Wei L, Calvisi DF, Chen X. Zhang S, et al. Am J Pathol. 2018 Apr;188(4):995-1006. doi: 10.1016/j.ajpath.2017.12.017. Epub 2018 Jan 31. Am J Pathol. 2018. PMID: 29378174 Free PMC article.
Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.
Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Wang J, et al. Among authors: zhang s. Oncogene. 2018 Jun;37(24):3229-3242. doi: 10.1038/s41388-018-0188-1. Epub 2018 Mar 16. Oncogene. 2018. PMID: 29545603 Free PMC article.
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Wang H, Wang J, Zhang S, Jia J, Liu X, Zhang J, Wang P, Song X, Che L, Liu K, Ribback S, Cigliano A, Evert M, Wu H, Calvisi DF, Zeng Y, Chen X. Wang H, et al. Among authors: zhang s, zhang j. Cell Mol Gastroenterol Hepatol. 2021;11(4):1095-1117. doi: 10.1016/j.jcmgh.2020.11.008. Epub 2020 Nov 21. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33232824 Free PMC article.
TAZ is indispensable for c-MYC-induced hepatocarcinogenesis.
Wang H, Zhang S, Zhang Y, Jia J, Wang J, Liu X, Zhang J, Song X, Ribback S, Cigliano A, Evert M, Liang B, Wu H, Calvisi DF, Zeng Y, Chen X. Wang H, et al. Among authors: zhang s, zhang j, zhang y. J Hepatol. 2022 Jan;76(1):123-134. doi: 10.1016/j.jhep.2021.08.021. Epub 2021 Aug 28. J Hepatol. 2022. PMID: 34464659 Free PMC article.
Corrigendum to 'TAZ is indispensable for c-MYC-induced hepatocarcinogenesis' [J Hepatol (2022) 123-134].
Wang H, Zhang S, Zhang Y, Jia J, Wang J, Liu X, Zhang J, Song X, Ribback S, Cigliano A, Evert M, Liang B, Wu H, Calvisi DF, Zeng Y, Chen X. Wang H, et al. Among authors: zhang s, zhang j, zhang y. J Hepatol. 2022 Mar;76(3):755-756. doi: 10.1016/j.jhep.2021.12.006. Epub 2021 Dec 26. J Hepatol. 2022. PMID: 34965902 Free PMC article. No abstract available.
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