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Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.
Li J, Wei H, Krystek SR Jr, Bond D, Brender TM, Cohen D, Feiner J, Hamacher N, Harshman J, Huang RY, Julien SH, Lin Z, Moore K, Mueller L, Noriega C, Sejwal P, Sheppard P, Stevens B, Chen G, Tymiak AA, Gross ML, Schneeweis LA. Li J, et al. Among authors: chen g. Anal Chem. 2017 Feb 21;89(4):2250-2258. doi: 10.1021/acs.analchem.6b03058. Epub 2017 Feb 9. Anal Chem. 2017. PMID: 28193005 Free PMC article.
A tris (2-carboxyethyl) phosphine (TCEP) related cleavage on cysteine-containing proteins.
Liu P, O'Mara BW, Warrack BM, Wu W, Huang Y, Zhang Y, Zhao R, Lin M, Ackerman MS, Hocknell PK, Chen G, Tao L, Rieble S, Wang J, Wang-Iverson DB, Tymiak AA, Grace MJ, Russell RJ. Liu P, et al. Among authors: chen g. J Am Soc Mass Spectrom. 2010 May;21(5):837-44. doi: 10.1016/j.jasms.2010.01.016. Epub 2010 Jan 28. J Am Soc Mass Spectrom. 2010. PMID: 20189823 Free article.
Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies.
Wang SJ, Wu ST, Gokemeijer J, Fura A, Krishna M, Morin P, Chen G, Price K, Wang-Iverson D, Olah T, Weiner R, Tymiak A, Jemal M. Wang SJ, et al. Among authors: chen g. Anal Bioanal Chem. 2012 Jan;402(3):1229-39. doi: 10.1007/s00216-011-5527-9. Epub 2011 Dec 1. Anal Bioanal Chem. 2012. PMID: 22130720
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