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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S. Xu H, et al. Among authors: saunders dn. Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432. Nat Commun. 2017. PMID: 28211448 Free PMC article.
Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.
Potratz JC, Saunders DN, Wai DH, Ng TL, McKinney SE, Carboni JM, Gottardis MM, Triche TJ, Jürgens H, Pollak MN, Aparicio SA, Sorensen PH. Potratz JC, et al. Among authors: saunders dn. Cancer Res. 2010 Nov 1;70(21):8770-81. doi: 10.1158/0008-5472.CAN-10-1093. Epub 2010 Oct 19. Cancer Res. 2010. PMID: 20959493
Revisiting the biological roles of PAI2 (SERPINB2) in cancer.
Croucher DR, Saunders DN, Lobov S, Ranson M. Croucher DR, et al. Among authors: saunders dn. Nat Rev Cancer. 2008 Jul;8(7):535-45. doi: 10.1038/nrc2400. Epub 2008 Jun 12. Nat Rev Cancer. 2008. PMID: 18548086 Review.
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.
Cipponi A, Goode DL, Bedo J, McCabe MJ, Pajic M, Croucher DR, Rajal AG, Junankar SR, Saunders DN, Lobachevsky P, Papenfuss AT, Nessem D, Nobis M, Warren SC, Timpson P, Cowley M, Vargas AC, Qiu MR, Generali DG, Keerthikumar S, Nguyen U, Corcoran NM, Long GV, Blay JY, Thomas DM. Cipponi A, et al. Among authors: saunders dn. Science. 2020 Jun 5;368(6495):1127-1131. doi: 10.1126/science.aau8768. Science. 2020. PMID: 32499442
EDD mediates DNA damage-induced activation of CHK2.
Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK. Henderson MJ, et al. Among authors: saunders dn. J Biol Chem. 2006 Dec 29;281(52):39990-40000. doi: 10.1074/jbc.M602818200. Epub 2006 Oct 30. J Biol Chem. 2006. PMID: 17074762 Free article.
Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
Hardie RA, van Dam E, Cowley M, Han TL, Balaban S, Pajic M, Pinese M, Iconomou M, Shearer RF, McKenna J, Miller D, Waddell N, Pearson JV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative; Sazanov L, Biankin AV, Villas-Boas S, Hoy AJ, Turner N, Saunders DN. Hardie RA, et al. Among authors: saunders dn. Cancer Metab. 2017 Jan 30;5:2. doi: 10.1186/s40170-017-0164-1. eCollection 2017. Cancer Metab. 2017. PMID: 28163917 Free PMC article.
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.
Farrawell NE, Lambert-Smith I, Mitchell K, McKenna J, McAlary L, Ciryam P, Vine KL, Saunders DN, Yerbury JJ. Farrawell NE, et al. Among authors: saunders dn. J Cell Sci. 2018 Jun 12;131(11):jcs209122. doi: 10.1242/jcs.209122. J Cell Sci. 2018. PMID: 29748379 Free PMC article.
65 results