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Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.
Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D. Schonauer S, et al. Among authors: dormann p. J Biol Chem. 2017 Apr 14;292(15):6177-6189. doi: 10.1074/jbc.M116.762831. Epub 2017 Mar 3. J Biol Chem. 2017. PMID: 28258214 Free PMC article.
Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes.
Ginkel C, Hartmann D, vom Dorp K, Zlomuzica A, Farwanah H, Eckhardt M, Sandhoff R, Degen J, Rabionet M, Dere E, Dörmann P, Sandhoff K, Willecke K. Ginkel C, et al. Among authors: dormann p. J Biol Chem. 2012 Dec 7;287(50):41888-902. doi: 10.1074/jbc.M112.413500. Epub 2012 Oct 16. J Biol Chem. 2012. PMID: 23074226 Free PMC article.
Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.
Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze JL, Dörmann P, Hartmann D, Bauer R, Willecke K. Bickert A, et al. Among authors: dormann p. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):734-749. doi: 10.1016/j.bbalip.2018.04.006. Epub 2018 Apr 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 29653252
Phytol metabolism in plants.
Gutbrod K, Romer J, Dörmann P. Gutbrod K, et al. Among authors: dormann p. Prog Lipid Res. 2019 Apr;74:1-17. doi: 10.1016/j.plipres.2019.01.002. Epub 2019 Jan 7. Prog Lipid Res. 2019. PMID: 30629961 Review.
Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.
Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D. Woeste MA, et al. Among authors: dormann p. J Biol Chem. 2019 Mar 15;294(11):3853-3871. doi: 10.1074/jbc.RA118.006311. Epub 2019 Jan 20. J Biol Chem. 2019. PMID: 30662006 Free PMC article.
162 results