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Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.
Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D. Schonauer S, et al. Among authors: wachten d. J Biol Chem. 2017 Apr 14;292(15):6177-6189. doi: 10.1074/jbc.M116.762831. Epub 2017 Mar 3. J Biol Chem. 2017. PMID: 28258214 Free PMC article.
A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm.
Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover SJ, Kaupp UB, Strünker T. Rennhack A, et al. Among authors: wachten d. Br J Pharmacol. 2018 Aug;175(15):3144-3161. doi: 10.1111/bph.14355. Epub 2018 Jun 29. Br J Pharmacol. 2018. PMID: 29723408 Free PMC article.
Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.
Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D. Woeste MA, et al. Among authors: wachten d. J Biol Chem. 2019 Mar 15;294(11):3853-3871. doi: 10.1074/jbc.RA118.006311. Epub 2019 Jan 20. J Biol Chem. 2019. PMID: 30662006 Free PMC article.
The Enigmatic Role of GBA2 in Controlling Locomotor Function.
Woeste MA, Wachten D. Woeste MA, et al. Among authors: wachten d. Front Mol Neurosci. 2017 Nov 28;10:386. doi: 10.3389/fnmol.2017.00386. eCollection 2017. Front Mol Neurosci. 2017. PMID: 29234271 Free PMC article. Review.
How to control cyclic nucleotide signaling by light.
Jansen V, Jikeli JF, Wachten D. Jansen V, et al. Among authors: wachten d. Curr Opin Biotechnol. 2017 Dec;48:15-20. doi: 10.1016/j.copbio.2017.02.014. Epub 2017 Mar 10. Curr Opin Biotechnol. 2017. PMID: 28288335 Review.
A novel biosensor to study cAMP dynamics in cilia and flagella.
Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D. Mukherjee S, et al. Among authors: wachten d. Elife. 2016 Mar 22;5:e14052. doi: 10.7554/eLife.14052. Elife. 2016. PMID: 27003291 Free PMC article.
62 results