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Role of the Notch signaling in cholangiocarcinoma.
Cigliano A, Wang J, Chen X, Calvisi DF. Cigliano A, et al. Among authors: chen x. Expert Opin Ther Targets. 2017 May;21(5):471-483. doi: 10.1080/14728222.2017.1310842. Epub 2017 Mar 30. Expert Opin Ther Targets. 2017. PMID: 28326864 Review.
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.
Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Zhang S, et al. Among authors: chen b, chen x. J Hepatol. 2017 Dec;67(6):1194-1203. doi: 10.1016/j.jhep.2017.07.006. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733220 Free PMC article.
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
Ho C, Wang C, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X, Calvisi DF. Ho C, et al. Among authors: chen x. Hepatology. 2012 Mar;55(3):833-45. doi: 10.1002/hep.24736. Epub 2011 Dec 19. Hepatology. 2012. PMID: 21993994 Free PMC article.
Cholangiocarcinomas can originate from hepatocytes in mice.
Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H. Fan B, et al. Among authors: chen x. J Clin Invest. 2012 Aug;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. J Clin Invest. 2012. PMID: 22797301 Free PMC article.
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