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Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library.
Khan L, Kumar R, Thiruvengadam R, Parray HA, Makhdoomi MA, Kumar S, Aggarwal H, Mohata M, Hussain AW, Das R, Varadarajan R, Bhattacharya J, Vajpayee M, Murugavel KG, Solomon S, Sinha S, Luthra K. Khan L, et al. Among authors: varadarajan r. Sci Rep. 2017 Mar 23;7:45163. doi: 10.1038/srep45163. Sci Rep. 2017. PMID: 28332627 Free PMC article.
Protein minimization of the gp120 binding region of human CD4.
Sharma D, Balamurali MM, Chakraborty K, Kumaran S, Jeganathan S, Rashid U, Ingallinella P, Varadarajan R. Sharma D, et al. Among authors: varadarajan r. Biochemistry. 2005 Dec 13;44(49):16192-202. doi: 10.1021/bi051120s. Biochemistry. 2005. PMID: 16331979
Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies.
Bhattacharyya S, Singh P, Rathore U, Purwar M, Wagner D, Arendt H, DeStefano J, LaBranche CC, Montefiori DC, Phogat S, Varadarajan R. Bhattacharyya S, et al. Among authors: varadarajan r. J Biol Chem. 2013 Apr 5;288(14):9815-9825. doi: 10.1074/jbc.M112.425959. Epub 2013 Feb 21. J Biol Chem. 2013. PMID: 23430741 Free PMC article.
A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques.
Jones AT, Chamcha V, Kesavardhana S, Shen X, Beaumont D, Das R, Wyatt LS, LaBranche CC, Stanfield-Oakley S, Ferrari G, Montefiori DC, Moss B, Tomaras GD, Varadarajan R, Amara RR. Jones AT, et al. Among authors: varadarajan r. J Virol. 2018 Feb 12;92(5):e01796-17. doi: 10.1128/JVI.01796-17. Print 2018 Mar 1. J Virol. 2018. PMID: 29237847 Free PMC article.
209 results