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The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation.
Parzych K, Saavedra-García P, Valbuena GN, Al-Sadah HA, Robinson ME, Penfold L, Kuzeva DM, Ruiz-Tellez A, Loaiza S, Holzmann V, Caputo V, Johnson DC, Kaiser MF, Karadimitris A, Lam EW, Chevet E, Feldhahn N, Keun HC, Auner HW. Parzych K, et al. Among authors: lam ew. Oncogene. 2019 Apr;38(17):3216-3231. doi: 10.1038/s41388-018-0651-z. Epub 2019 Jan 9. Oncogene. 2019. PMID: 30626938 Free PMC article.
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression.
Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S, Wymann MP, Brosens JJ, Schulze A, Lam EW. Hui RC, et al. Among authors: lam ew. Mol Cell Biol. 2008 Oct;28(19):5886-98. doi: 10.1128/MCB.01265-07. Epub 2008 Jul 21. Mol Cell Biol. 2008. PMID: 18644865 Free PMC article.
Many forks in the path: cycling with FoxO.
Ho KK, Myatt SS, Lam EW. Ho KK, et al. Among authors: lam ew. Oncogene. 2008 Apr 7;27(16):2300-11. doi: 10.1038/onc.2008.23. Oncogene. 2008. PMID: 18391972 Review.
369 results