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Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.
EMBO Mol Med. 2017 Jul;9(7):859-868. doi: 10.15252/emmm.201607486.
EMBO Mol Med. 2017.
PMID: 28408402
Free PMC article.
Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins.
Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, Klopstock T, Hermann A, Haass C, Edbauer D.
Zhou Q, et al. Among authors: lehmer c.
EMBO Mol Med. 2017 May;9(5):687-702. doi: 10.15252/emmm.201607054.
EMBO Mol Med. 2017.
PMID: 28351931
Free PMC article.
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RNA versus protein toxicity in C9orf72 ALS/FTLD.
Arzberger T, Schludi MH, Lehmer C, Schmid B, Edbauer D.
Arzberger T, et al. Among authors: lehmer c.
Acta Neuropathol. 2018 Mar;135(3):475-479. doi: 10.1007/s00401-018-1823-1. Epub 2018 Feb 15.
Acta Neuropathol. 2018.
PMID: 29450647
No abstract available.
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A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.
Lehmer C, Schludi MH, Ransom L, Greiling J, Junghänel M, Exner N, Riemenschneider H, van der Zee J, Van Broeckhoven C, Weydt P, Heneka MT, Edbauer D.
Lehmer C, et al.
EMBO Mol Med. 2018 Jun;10(6):e8558. doi: 10.15252/emmm.201708558.
EMBO Mol Med. 2018.
PMID: 29789341
Free PMC article.
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In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.
Guo Q, et al. Among authors: lehmer c.
Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.
Cell. 2018.
PMID: 29398115
Free PMC article.
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Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation.
Spahiu L, Ålander J, Ottosson-Wadlund A, Svensson R, Lehmer C, Armstrong RN, Morgenstern R.
Spahiu L, et al. Among authors: lehmer c.
Biochemistry. 2017 Jun 20;56(24):3089-3098. doi: 10.1021/acs.biochem.7b00285. Epub 2017 Jun 9.
Biochemistry. 2017.
PMID: 28558199
Free PMC article.
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