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JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium.
Sacherer M, Sedej S, Wakuła P, Wallner M, Vos MA, Kockskämper J, Stiegler P, Sereinigg M, von Lewinski D, Antoons G, Pieske BM, Heinzel FR; CONTICA investigators. Sacherer M, et al. Among authors: heinzel fr. Br J Pharmacol. 2012 Oct;167(3):493-504. doi: 10.1111/j.1476-5381.2012.01995.x. Br J Pharmacol. 2012. PMID: 22509897 Free PMC article.
Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure.
Hohendanner F, Ljubojević S, MacQuaide N, Sacherer M, Sedej S, Biesmans L, Wakula P, Platzer D, Sokolow S, Herchuelz A, Antoons G, Sipido K, Pieske B, Heinzel FR. Hohendanner F, et al. Among authors: heinzel fr. Circ Res. 2013 Aug 16;113(5):527-38. doi: 10.1161/CIRCRESAHA.113.300895. Epub 2013 Jul 3. Circ Res. 2013. PMID: 23825358
European Heart Rhythm Association/Heart Failure Association joint consensus document on arrhythmias in heart failure, endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society.
Lip GY, Heinzel FR, Gaita F, Juanatey JR, Le Heuzey JY, Potpara T, Svendsen JH, Vos MA, Anker SD, Coats AJ, Haverkamp W, Manolis AS, Chung MK, Sanders P, Pieske B, Gorenek B, Lane D, Boriani G, Linde C, Hindricks G, Tsutsui H, Homma S, Brownstein S, Nielsen JC, Lainscak M, Crespo-Leiro M, Piepoli M, Seferovic P, Savelieva I. Lip GY, et al. Among authors: heinzel fr. Europace. 2016 Jan;18(1):12-36. doi: 10.1093/europace/euv191. Epub 2015 Aug 21. Europace. 2016. PMID: 26297713 No abstract available.
AMP-activated protein kinase α1-sensitive activation of AP-1 in cardiomyocytes.
Voelkl J, Alesutan I, Primessnig U, Feger M, Mia S, Jungmann A, Castor T, Viereck R, Stöckigt F, Borst O, Gawaz M, Schrickel JW, Metzler B, Katus HA, Müller OJ, Pieske B, Heinzel FR, Lang F. Voelkl J, et al. Among authors: heinzel fr. J Mol Cell Cardiol. 2016 Aug;97:36-43. doi: 10.1016/j.yjmcc.2016.04.009. Epub 2016 Apr 19. J Mol Cell Cardiol. 2016. PMID: 27106803
108 results