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DNA single-strand break-induced DNA damage response causes heart failure.
Higo T, Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa A, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, McKinnon PJ, Sakata Y, Komuro I. Higo T, et al. Among authors: hikoso s. Nat Commun. 2017 Apr 24;8:15104. doi: 10.1038/ncomms15104. Nat Commun. 2017. PMID: 28436431 Free PMC article.
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K. Mizote I, et al. Among authors: hikoso s. J Mol Cell Cardiol. 2010 Feb;48(2):302-9. doi: 10.1016/j.yjmcc.2009.10.010. Epub 2009 Oct 20. J Mol Cell Cardiol. 2010. PMID: 19850048
Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Takuji Shirasawa TS, Mizushima N, Otsu K. Taneike M, et al. Among authors: hikoso s. Autophagy. 2010 Jul;6(5):600-6. doi: 10.4161/auto.6.5.11947. Epub 2010 Jul 1. Autophagy. 2010. PMID: 20431347
Calpain protects the heart from hemodynamic stress.
Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K. Taneike M, et al. Among authors: hikoso s. J Biol Chem. 2011 Sep 16;286(37):32170-7. doi: 10.1074/jbc.M111.248088. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795695 Free PMC article.
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K. Murakawa T, et al. Among authors: hikoso s. Nat Commun. 2015 Jul 6;6:7527. doi: 10.1038/ncomms8527. Nat Commun. 2015. PMID: 26146385 Free PMC article.
166 results