Del Valle JR - Search Results

1

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.

Tavernier SJ, Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CC, Lambrecht BN, Janssens S. Tavernier SJ, et al. Among authors: del valle jr. Nat Cell Biol. 2017 Jun;19(6):698-710. doi: 10.1038/ncb3518. Epub 2017 May 1. Nat Cell Biol. 2017. PMID: 28459443 Free PMC article.

2

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC. Tang CH, et al. Among authors: del valle jr. J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6. J Cell Biol. 2018. PMID: 29511123 Free PMC article.

3

Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.

Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q. Liu L, et al. Nat Cell Biol. 2019 Mar;21(3):328-337. doi: 10.1038/s41556-019-0285-6. Epub 2019 Feb 18. Nat Cell Biol. 2019. PMID: 30778220 Free PMC article.

4

IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.

Xie H, Tang CH, Song JH, Mancuso A, Del Valle JR, Cao J, Xiang Y, Dang CV, Lan R, Sanchez DJ, Keith B, Hu CC, Simon MC. Xie H, et al. Among authors: del valle jr. J Clin Invest. 2018 Apr 2;128(4):1300-1316. doi: 10.1172/JCI95864. Epub 2018 Feb 26. J Clin Invest. 2018. PMID: 29381485 Free PMC article.

5

Clarifying the translational potential of B-I09.

Del Valle JR, Betts BC, Yu XZ, Janssens S, Lambrecht BN, Simon MC, Hu CA. Del Valle JR, et al. Nat Chem Biol. 2020 Nov;16(11):1152. doi: 10.1038/s41589-020-00654-w. Nat Chem Biol. 2020. PMID: 33067597 Free PMC article. No abstract available.

6

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.

Tang CH, Zundell JA, Ranatunga S, Lin C, Nefedova Y, Del Valle JR, Hu CC. Tang CH, et al. Among authors: del valle jr. Cancer Res. 2016 Apr 15;76(8):2137-52. doi: 10.1158/0008-5472.CAN-15-1885. Epub 2016 Mar 7. Cancer Res. 2016. PMID: 26951929 Free PMC article.

7

Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.

Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ. Schutt SD, et al. Among authors: del valle jr. Blood Adv. 2018 Feb 27;2(4):414-427. doi: 10.1182/bloodadvances.2017009068. Blood Adv. 2018. PMID: 29483082 Free PMC article.

8

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity.

Shao A, Kang CW, Tang CH, Cain CF, Xu Q, Phoumyvong CM, Del Valle JR, Hu CC. Shao A, et al. Among authors: del valle jr. J Med Chem. 2019 Jun 13;62(11):5404-5413. doi: 10.1021/acs.jmedchem.9b00269. Epub 2019 May 22. J Med Chem. 2019. PMID: 31083990 Free PMC article.

9

Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.

Ranatunga S, Tang CH, Kang CW, Kriss CL, Kloppenburg BJ, Hu CC, Del Valle JR. Ranatunga S, et al. Among authors: del valle jr. J Med Chem. 2014 May 22;57(10):4289-301. doi: 10.1021/jm5002452. Epub 2014 May 2. J Med Chem. 2014. PMID: 24749861 Free PMC article.

10

Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

Tang CH, Ranatunga S, Kriss CL, Cubitt CL, Tao J, Pinilla-Ibarz JA, Del Valle JR, Hu CC. Tang CH, et al. Among authors: del valle jr. J Clin Invest. 2014 Jun;124(6):2585-98. doi: 10.1172/JCI73448. Epub 2014 May 8. J Clin Invest. 2014. PMID: 24812669 Free PMC article.

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